Combating Root-Knot Nematodes (<i>Meloidogyne</i> spp.): From Molecular Mechanisms to Resistant Crops
Root-knot nematodes (RKNs; <i>Meloidogyne</i> spp.) are significant plant–parasitic nematodes that cause major yield losses worldwide. With growing awareness of the harmful effects of chemical pesticides on human health and the environment, there is an urgent need to develop alternative...
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MDPI AG
2025-04-01
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| Series: | Plants |
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| author | Himanshu Yadav Philip A. Roberts Damar Lopez-Arredondo |
| author_facet | Himanshu Yadav Philip A. Roberts Damar Lopez-Arredondo |
| author_sort | Himanshu Yadav |
| collection | DOAJ |
| description | Root-knot nematodes (RKNs; <i>Meloidogyne</i> spp.) are significant plant–parasitic nematodes that cause major yield losses worldwide. With growing awareness of the harmful effects of chemical pesticides on human health and the environment, there is an urgent need to develop alternative strategies for controlling RKN in agricultural fields. In recent years, implementing multiple approaches based on transcriptomics, genomics, and genome engineering, including modern platforms like CRISPR/Cas9, along with traditional genetic mapping, has led to great advances in understanding the plant–RKN interactions and the underlying molecular mechanisms of plant RKN resistance. In this literature review, we synthesize the contributions of relevant studies in this field and discuss key findings. This includes, for instance, transcriptomics studies that helped expand our understanding of plant RKN-resistance mechanisms, the overexpression of plant hormone-related genes, and the silencing of susceptibility genes that lead to plant RKN resistance. This review was conducted by searching scientific sources, including PubMed and Google Scholar, for relevant publications and filtering them using keywords such as RKN–plant defense mechanisms, host–plant resistance against RKN, and genetic mapping for RKN. This knowledge can be leveraged to accelerate the development of RKN-resistant plants and substantially improve RKN management in economically important crops. |
| format | Article |
| id | doaj-art-6373b844ec4c4ab78de1a5bac3d6fcd6 |
| institution | OA Journals |
| issn | 2223-7747 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Plants |
| spelling | doaj-art-6373b844ec4c4ab78de1a5bac3d6fcd62025-08-20T02:31:03ZengMDPI AGPlants2223-77472025-04-01149132110.3390/plants14091321Combating Root-Knot Nematodes (<i>Meloidogyne</i> spp.): From Molecular Mechanisms to Resistant CropsHimanshu Yadav0Philip A. Roberts1Damar Lopez-Arredondo2Institute of Genomics for Crop Abiotic Stress Tolerance, Department of Plant and Soil Science, Texas Tech University, Lubbock, TX 79409, USADepartment of Nematology, University of California, Riverside, CA 92521, USAInstitute of Genomics for Crop Abiotic Stress Tolerance, Department of Plant and Soil Science, Texas Tech University, Lubbock, TX 79409, USARoot-knot nematodes (RKNs; <i>Meloidogyne</i> spp.) are significant plant–parasitic nematodes that cause major yield losses worldwide. With growing awareness of the harmful effects of chemical pesticides on human health and the environment, there is an urgent need to develop alternative strategies for controlling RKN in agricultural fields. In recent years, implementing multiple approaches based on transcriptomics, genomics, and genome engineering, including modern platforms like CRISPR/Cas9, along with traditional genetic mapping, has led to great advances in understanding the plant–RKN interactions and the underlying molecular mechanisms of plant RKN resistance. In this literature review, we synthesize the contributions of relevant studies in this field and discuss key findings. This includes, for instance, transcriptomics studies that helped expand our understanding of plant RKN-resistance mechanisms, the overexpression of plant hormone-related genes, and the silencing of susceptibility genes that lead to plant RKN resistance. This review was conducted by searching scientific sources, including PubMed and Google Scholar, for relevant publications and filtering them using keywords such as RKN–plant defense mechanisms, host–plant resistance against RKN, and genetic mapping for RKN. This knowledge can be leveraged to accelerate the development of RKN-resistant plants and substantially improve RKN management in economically important crops.https://www.mdpi.com/2223-7747/14/9/1321<i>Meloidogyne</i> spp.root-knot nematodesplant defense systemmolecular breedingomicsgenetic engineering |
| spellingShingle | Himanshu Yadav Philip A. Roberts Damar Lopez-Arredondo Combating Root-Knot Nematodes (<i>Meloidogyne</i> spp.): From Molecular Mechanisms to Resistant Crops Plants <i>Meloidogyne</i> spp. root-knot nematodes plant defense system molecular breeding omics genetic engineering |
| title | Combating Root-Knot Nematodes (<i>Meloidogyne</i> spp.): From Molecular Mechanisms to Resistant Crops |
| title_full | Combating Root-Knot Nematodes (<i>Meloidogyne</i> spp.): From Molecular Mechanisms to Resistant Crops |
| title_fullStr | Combating Root-Knot Nematodes (<i>Meloidogyne</i> spp.): From Molecular Mechanisms to Resistant Crops |
| title_full_unstemmed | Combating Root-Knot Nematodes (<i>Meloidogyne</i> spp.): From Molecular Mechanisms to Resistant Crops |
| title_short | Combating Root-Knot Nematodes (<i>Meloidogyne</i> spp.): From Molecular Mechanisms to Resistant Crops |
| title_sort | combating root knot nematodes i meloidogyne i spp from molecular mechanisms to resistant crops |
| topic | <i>Meloidogyne</i> spp. root-knot nematodes plant defense system molecular breeding omics genetic engineering |
| url | https://www.mdpi.com/2223-7747/14/9/1321 |
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