Impact of Some Vitamins and Minerals Supplements on Type 2 Diabetes (T2DM) Management
A chronic metabolic condition, type 2 diabetes mellitus (T2DM) typically presents with hyperglycemia owing to elevated tissue insulin resistance or inadequate insulin release. In addition to the use of pharmaceutical agents and lifestyle changes for the management of T2DM, supplementation with vario...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Brawijaya
2024-05-01
|
| Series: | Journal of Tropical Life Science |
| Subjects: | |
| Online Access: | https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/3064 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850106324723957760 |
|---|---|
| author | Karar Nadhum Jawad Musafer Amera Kamal Mohammed Ali Sabah Chobok Masar Riyadh Rashid AL-Mousawi Fahrul Huyop Tahreer M. Al-Thuwaini |
| author_facet | Karar Nadhum Jawad Musafer Amera Kamal Mohammed Ali Sabah Chobok Masar Riyadh Rashid AL-Mousawi Fahrul Huyop Tahreer M. Al-Thuwaini |
| author_sort | Karar Nadhum Jawad Musafer |
| collection | DOAJ |
| description | A chronic metabolic condition, type 2 diabetes mellitus (T2DM) typically presents with hyperglycemia owing to elevated tissue insulin resistance or inadequate insulin release. In addition to the use of pharmaceutical agents and lifestyle changes for the management of T2DM, supplementation with various vitamins and minerals has also been proven to be of benefit. The objective of the present research was to establish the effectiveness of vitamin B12, vitamin C, selenium, and chromium as adjunctive therapy given over 120 days in diminishing insulin resistance. In total, 32 individuals (16 men and 16 women) living with diabetes were enrolled in the study. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), serum insulin concentrations, and homeostatic model assessment of insulin resistance (HOMA-IR) were quantified at baseline and on day 120 of supplementation. Mean FBG and HbA1c levels and insulin concentrations all decreased, i.e. 185.11 ± 22.67 mg/dL vs. 163.57 ± 19.31 mg/dL (P = 0.02), 8.47 ± 0.52% vs. 7.80 ± 0.48% (P = 0.003), and 23.15 ± 3.87 vs. 15.85 ± 1.46 (P = 0.02), respectively. HOMA-IR values remained unchanged. The association between therapy and clinical features was examined using logistic regression analysis. In the subjects with T2DM, FBG, and HbA1c levels were diminished by a factor of 2. It was concluded that vitamin and mineral supplementation was of benefit with respect to glycemic parameters. Nevertheless, high-quality evidence that supports the efficacy of such substances to improve glucose homeostasis and insulin resistance in individuals with T2DM in a clinical setting is lacking |
| format | Article |
| id | doaj-art-6372114e4de543c9be54ea51b2634d3e |
| institution | OA Journals |
| issn | 2087-5517 2527-4376 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | University of Brawijaya |
| record_format | Article |
| series | Journal of Tropical Life Science |
| spelling | doaj-art-6372114e4de543c9be54ea51b2634d3e2025-08-20T02:38:51ZengUniversity of BrawijayaJournal of Tropical Life Science2087-55172527-43762024-05-0114221121610.11594/jtls.14.02.013009Impact of Some Vitamins and Minerals Supplements on Type 2 Diabetes (T2DM) ManagementKarar Nadhum Jawad Musafer0https://orcid.org/0000-0002-3713-7444Amera Kamal Mohammed1Ali Sabah Chobok2Masar Riyadh Rashid AL-Mousawi3Fahrul Huyop4Tahreer M. Al-Thuwaini5Molecular Clinical Biochemistry Pharmecy Department, Al-Zahrawi University College, IraqClinical laboratory sciences Department., College of pharmacy, University of KirkukDepartment of Pharmacy, Al-Zahrawi University College(Departmet of Microbiology, Collage of Medicine, Kerbela UniversityDepartment of Biosciences, Faculty of Science, Universiti Teknologi MalaysiaDepartment of Animal Production, College of Agriculture, Al-Qasim Green University, Al-QasimA chronic metabolic condition, type 2 diabetes mellitus (T2DM) typically presents with hyperglycemia owing to elevated tissue insulin resistance or inadequate insulin release. In addition to the use of pharmaceutical agents and lifestyle changes for the management of T2DM, supplementation with various vitamins and minerals has also been proven to be of benefit. The objective of the present research was to establish the effectiveness of vitamin B12, vitamin C, selenium, and chromium as adjunctive therapy given over 120 days in diminishing insulin resistance. In total, 32 individuals (16 men and 16 women) living with diabetes were enrolled in the study. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), serum insulin concentrations, and homeostatic model assessment of insulin resistance (HOMA-IR) were quantified at baseline and on day 120 of supplementation. Mean FBG and HbA1c levels and insulin concentrations all decreased, i.e. 185.11 ± 22.67 mg/dL vs. 163.57 ± 19.31 mg/dL (P = 0.02), 8.47 ± 0.52% vs. 7.80 ± 0.48% (P = 0.003), and 23.15 ± 3.87 vs. 15.85 ± 1.46 (P = 0.02), respectively. HOMA-IR values remained unchanged. The association between therapy and clinical features was examined using logistic regression analysis. In the subjects with T2DM, FBG, and HbA1c levels were diminished by a factor of 2. It was concluded that vitamin and mineral supplementation was of benefit with respect to glycemic parameters. Nevertheless, high-quality evidence that supports the efficacy of such substances to improve glucose homeostasis and insulin resistance in individuals with T2DM in a clinical setting is lackinghttps://jtrolis.ub.ac.id/index.php/jtrolis/article/view/3064b12homa-irmineralstype 2 diabetes mellitusvitamins |
| spellingShingle | Karar Nadhum Jawad Musafer Amera Kamal Mohammed Ali Sabah Chobok Masar Riyadh Rashid AL-Mousawi Fahrul Huyop Tahreer M. Al-Thuwaini Impact of Some Vitamins and Minerals Supplements on Type 2 Diabetes (T2DM) Management Journal of Tropical Life Science b12 homa-ir minerals type 2 diabetes mellitus vitamins |
| title | Impact of Some Vitamins and Minerals Supplements on Type 2 Diabetes (T2DM) Management |
| title_full | Impact of Some Vitamins and Minerals Supplements on Type 2 Diabetes (T2DM) Management |
| title_fullStr | Impact of Some Vitamins and Minerals Supplements on Type 2 Diabetes (T2DM) Management |
| title_full_unstemmed | Impact of Some Vitamins and Minerals Supplements on Type 2 Diabetes (T2DM) Management |
| title_short | Impact of Some Vitamins and Minerals Supplements on Type 2 Diabetes (T2DM) Management |
| title_sort | impact of some vitamins and minerals supplements on type 2 diabetes t2dm management |
| topic | b12 homa-ir minerals type 2 diabetes mellitus vitamins |
| url | https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/3064 |
| work_keys_str_mv | AT kararnadhumjawadmusafer impactofsomevitaminsandmineralssupplementsontype2diabetest2dmmanagement AT amerakamalmohammed impactofsomevitaminsandmineralssupplementsontype2diabetest2dmmanagement AT alisabahchobok impactofsomevitaminsandmineralssupplementsontype2diabetest2dmmanagement AT masarriyadhrashidalmousawi impactofsomevitaminsandmineralssupplementsontype2diabetest2dmmanagement AT fahrulhuyop impactofsomevitaminsandmineralssupplementsontype2diabetest2dmmanagement AT tahreermalthuwaini impactofsomevitaminsandmineralssupplementsontype2diabetest2dmmanagement |