Novel dual action chimera doxorubizen demonstrates superior efficacy to doxorubicin in acute leukemia

Novel dual action chimera doxorubizen demonstrates superior efficacy to doxorubicin in acute leukemia

Abstract Modifying existing drugs to enhance their activity and reduce toxicity is a major focus of drug development. We developed a novel class of dual-action chimeric molecules for cancer therapy, linking known drugs to a DNA-methylating monomethyl triazene moiety (azene) via nucleophilic substitu...

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Bibliographic Details
Main Authors: Dipak Walunj, Katarina Egarmina, Adi Zipin-Roitman, Siva Sai Naga Anurag Muddineni, Iryna Tkachenko, Pousali Mitra, Dror Tobi, Andrii Bazylevich, Ofer Shpilberg, Michael Milyavsky, Oshrat Hershkovitz-Rokah, Gary Gellerman
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Anticancer drug
DNA intercalation
DNA double-strand breaks
Molecular
Online Access:https://doi.org/10.1038/s41598-025-94373-8
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