Animal models for emerging coronavirus: progress and new insights
The emergences of coronaviruses have caused a serious global public health problem because their infection in humans caused the severe acute respiratory disease and deaths. The outbreaks of lethal coronaviruses have taken place for three times within recent two decades (SARS-CoV in 2002, MERS-CoV in...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2020.1764871 |
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| _version_ | 1850150290621202432 |
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| author | Lunzhi Yuan Qiyi Tang Tong Cheng Ningshao Xia |
| author_facet | Lunzhi Yuan Qiyi Tang Tong Cheng Ningshao Xia |
| author_sort | Lunzhi Yuan |
| collection | DOAJ |
| description | The emergences of coronaviruses have caused a serious global public health problem because their infection in humans caused the severe acute respiratory disease and deaths. The outbreaks of lethal coronaviruses have taken place for three times within recent two decades (SARS-CoV in 2002, MERS-CoV in 2012 and SARS-CoV-2 in 2019). Much more serious than SARS-CoV in 2002, the current SARS-CoV-2 infection has been spreading to more than 213 countries, areas or territories and causing more than two million cases up to date (17 April 2020). Unfortunately, no vaccine and specific anti-coronavirus drugs are available at present time. Current clinical treatment at hand is inadequate to suppress viral replication and inflammation, and reverse organ failure. Intensive research efforts have focused on increasing our understanding of viral biology of SARS-CoV-2, improving antiviral therapy and vaccination strategies. The animal models are important for both the fundamental research and drug discovery of coronavirus. This review aims to summarize the animal models currently available for SARS-CoV and MERS-CoV, and their potential use for the study of SARS-CoV-2. We will discuss the benefits and caveats of these animal models and present critical findings that might guide the fundamental studies and urgent treatment of SARS-CoV-2-caused diseases. |
| format | Article |
| id | doaj-art-6366ccfd2e3249f0afb975da8b9736fa |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-6366ccfd2e3249f0afb975da8b9736fa2025-08-20T02:26:36ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512020-01-019194996110.1080/22221751.2020.1764871Animal models for emerging coronavirus: progress and new insightsLunzhi Yuan0Qiyi Tang1Tong Cheng2Ningshao Xia3State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, PR People’s Republic of ChinaDepartment of Microbiology, Howard University College of Medicine, Washington, DC, USAState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, PR People’s Republic of ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, PR People’s Republic of ChinaThe emergences of coronaviruses have caused a serious global public health problem because their infection in humans caused the severe acute respiratory disease and deaths. The outbreaks of lethal coronaviruses have taken place for three times within recent two decades (SARS-CoV in 2002, MERS-CoV in 2012 and SARS-CoV-2 in 2019). Much more serious than SARS-CoV in 2002, the current SARS-CoV-2 infection has been spreading to more than 213 countries, areas or territories and causing more than two million cases up to date (17 April 2020). Unfortunately, no vaccine and specific anti-coronavirus drugs are available at present time. Current clinical treatment at hand is inadequate to suppress viral replication and inflammation, and reverse organ failure. Intensive research efforts have focused on increasing our understanding of viral biology of SARS-CoV-2, improving antiviral therapy and vaccination strategies. The animal models are important for both the fundamental research and drug discovery of coronavirus. This review aims to summarize the animal models currently available for SARS-CoV and MERS-CoV, and their potential use for the study of SARS-CoV-2. We will discuss the benefits and caveats of these animal models and present critical findings that might guide the fundamental studies and urgent treatment of SARS-CoV-2-caused diseases.https://www.tandfonline.com/doi/10.1080/22221751.2020.1764871Coronavirusinfectious diseaserespiratory syndromeanimal modelvaccine and drug discovery |
| spellingShingle | Lunzhi Yuan Qiyi Tang Tong Cheng Ningshao Xia Animal models for emerging coronavirus: progress and new insights Emerging Microbes and Infections Coronavirus infectious disease respiratory syndrome animal model vaccine and drug discovery |
| title | Animal models for emerging coronavirus: progress and new insights |
| title_full | Animal models for emerging coronavirus: progress and new insights |
| title_fullStr | Animal models for emerging coronavirus: progress and new insights |
| title_full_unstemmed | Animal models for emerging coronavirus: progress and new insights |
| title_short | Animal models for emerging coronavirus: progress and new insights |
| title_sort | animal models for emerging coronavirus progress and new insights |
| topic | Coronavirus infectious disease respiratory syndrome animal model vaccine and drug discovery |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2020.1764871 |
| work_keys_str_mv | AT lunzhiyuan animalmodelsforemergingcoronavirusprogressandnewinsights AT qiyitang animalmodelsforemergingcoronavirusprogressandnewinsights AT tongcheng animalmodelsforemergingcoronavirusprogressandnewinsights AT ningshaoxia animalmodelsforemergingcoronavirusprogressandnewinsights |