The role of exosomes in the mechanisms of inflammation development in patients with cardiovascular pathology and the contribution to therapeutic potential of stem cells
The aim – based on the analysis of the scientific literature focused on understanding the role of exosomes in the mechanisms of inflammation development and application of stem cells for cellular therapy in different pathological conditions, to identify and substantiate the prospects of using the ex...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2021-07-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/204886/236546 |
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| author | P. F. Muzychenko Zh. M. Minchenko T. I. Havrylenko V. A. Cherniak S. V. Demidov N. O. Ryzhkova O. A. Pidhaina |
| author_facet | P. F. Muzychenko Zh. M. Minchenko T. I. Havrylenko V. A. Cherniak S. V. Demidov N. O. Ryzhkova O. A. Pidhaina |
| author_sort | P. F. Muzychenko |
| collection | DOAJ |
| description | The aim – based on the analysis of the scientific literature focused on understanding the role of exosomes in the mechanisms of inflammation development and application of stem cells for cellular therapy in different pathological conditions, to identify and substantiate the prospects of using the exosomes as prognostic markers of a disease progression and application of their therapeutic potential in cardiovascular pathology.
Global trends in the study of stem cells of different origins from the perspective of morphofunctional, molecular-genetic, cytogenetic, immunogenetic and cytological characteristics contribute significantly the development of regenerative medicine in the context of developing new methodological solutions for the use of stem cells and their components, particularly exosomes, for cell therapy of various pathological conditions. Studies show the indirect effect of exosomes on the immune response activation, coordination of cellular senescence processes and antigen presentation. There are also evidence of their impact on the structural and functional restoration of affected organs and blood vessels.
The application potential of exosomes in practical medicine, particularly in the area of new approaches development to synthesize the newer biopharmaceuticals and as markers of multifactorial pathology course in conjunction with studies on the mechanisms of exosome involvement into immune processes is discussed.
The study on the exosome-mediated mechanisms of inflammation in atherosclerosis is relevant, given the fact that their main physiological role is to implement the link between immunocompetent cells.
Conclusions. Improving knowledge of the molecular biological mechanisms of the exosome influence on immunological processes in patients with cardiovascular pathology allows to expand the range of diagnostic and prognostic criteria for the formation of immuno-inflammatory reactions and endothelial dysfunction and to outline ways to personify the choice of therapeutic programs, which, in turn, can open approaches to develop fundamentally newer pharmaceuticals. |
| format | Article |
| id | doaj-art-6366456343874a2fa66787d22afe35f2 |
| institution | OA Journals |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-6366456343874a2fa66787d22afe35f22025-08-20T02:35:13ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102021-07-0123456657410.14739/2310-1210.2021.4.204886The role of exosomes in the mechanisms of inflammation development in patients with cardiovascular pathology and the contribution to therapeutic potential of stem cellsP. F. Muzychenko0https://orcid.org/0000-0001-7876-106XZh. M. Minchenko1https://orcid.org/0000-0002-9152-5595T. I. Havrylenko2https://orcid.org/0000-0002-1905-8240V. A. Cherniak3https://orcid.org/0000-0001-8424-4691S. V. Demidov4N. O. Ryzhkova5https://orcid.org/0000-0002-5341-0594O. A. Pidhaina6https://orcid.org/0000-0003-2388-3275Bogomolets National Medical University, Kyiv, UkraineSI “National Research Center for Radiation Medicine of the NAMS of Ukraine”, KyivSI “National Scientific Center “Institute of Cardiology named after M. D. Strazhesko” of the NAMS of Ukraine, KyivTaras Shevchenko National University, Kyiv, UkraineTaras Shevchenko National University, Kyiv, UkraineSI “National Scientific Center "Institute of Cardiology named after M. D. Strazhesko” of the NAMS of Ukraine, KyivSI “National Scientific Center "Institute of Cardiology named after M. D. Strazhesko” of the NAMS of Ukraine, KyivThe aim – based on the analysis of the scientific literature focused on understanding the role of exosomes in the mechanisms of inflammation development and application of stem cells for cellular therapy in different pathological conditions, to identify and substantiate the prospects of using the exosomes as prognostic markers of a disease progression and application of their therapeutic potential in cardiovascular pathology. Global trends in the study of stem cells of different origins from the perspective of morphofunctional, molecular-genetic, cytogenetic, immunogenetic and cytological characteristics contribute significantly the development of regenerative medicine in the context of developing new methodological solutions for the use of stem cells and their components, particularly exosomes, for cell therapy of various pathological conditions. Studies show the indirect effect of exosomes on the immune response activation, coordination of cellular senescence processes and antigen presentation. There are also evidence of their impact on the structural and functional restoration of affected organs and blood vessels. The application potential of exosomes in practical medicine, particularly in the area of new approaches development to synthesize the newer biopharmaceuticals and as markers of multifactorial pathology course in conjunction with studies on the mechanisms of exosome involvement into immune processes is discussed. The study on the exosome-mediated mechanisms of inflammation in atherosclerosis is relevant, given the fact that their main physiological role is to implement the link between immunocompetent cells. Conclusions. Improving knowledge of the molecular biological mechanisms of the exosome influence on immunological processes in patients with cardiovascular pathology allows to expand the range of diagnostic and prognostic criteria for the formation of immuno-inflammatory reactions and endothelial dysfunction and to outline ways to personify the choice of therapeutic programs, which, in turn, can open approaches to develop fundamentally newer pharmaceuticals.http://zmj.zsmu.edu.ua/article/view/204886/236546exosomesinflammationcardiovascular diseasesstem cells |
| spellingShingle | P. F. Muzychenko Zh. M. Minchenko T. I. Havrylenko V. A. Cherniak S. V. Demidov N. O. Ryzhkova O. A. Pidhaina The role of exosomes in the mechanisms of inflammation development in patients with cardiovascular pathology and the contribution to therapeutic potential of stem cells Zaporožskij Medicinskij Žurnal exosomes inflammation cardiovascular diseases stem cells |
| title | The role of exosomes in the mechanisms of inflammation development in patients with cardiovascular pathology and the contribution to therapeutic potential of stem cells |
| title_full | The role of exosomes in the mechanisms of inflammation development in patients with cardiovascular pathology and the contribution to therapeutic potential of stem cells |
| title_fullStr | The role of exosomes in the mechanisms of inflammation development in patients with cardiovascular pathology and the contribution to therapeutic potential of stem cells |
| title_full_unstemmed | The role of exosomes in the mechanisms of inflammation development in patients with cardiovascular pathology and the contribution to therapeutic potential of stem cells |
| title_short | The role of exosomes in the mechanisms of inflammation development in patients with cardiovascular pathology and the contribution to therapeutic potential of stem cells |
| title_sort | role of exosomes in the mechanisms of inflammation development in patients with cardiovascular pathology and the contribution to therapeutic potential of stem cells |
| topic | exosomes inflammation cardiovascular diseases stem cells |
| url | http://zmj.zsmu.edu.ua/article/view/204886/236546 |
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