Assessment of genetically modified maize DP910521 (application GMFF‐2021‐2473)
Abstract Genetically modified (GM) maize DP910521 was developed to confer resistance against certain lepidopteran insect pests as well as tolerance to glufosinate herbicide; these properties were achieved by introducing the mo‐pat, pmi and cry1B.34 expression cassettes. The molecular characterisatio...
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Wiley
2024-08-01
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| Online Access: | https://doi.org/10.2903/j.efsa.2024.8887 |
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| author | EFSA Panel on Genetically Modified Organisms (GMO) Ewen Mullins Jean‐Louis Bresson Tamas Dalmay Ian Crawford Dewhurst Michelle M. Epstein Leslie George Firbank Philippe Guerche Jan Hejatko Hanspeter Naegeli Francisco Javier Moreno Fabien Nogué Nils Rostoks Jose Juan Sánchez Serrano Giovanni Savoini Eve Veromann Fabio Veronesi Michele Ardizzone Giacomo De Sanctis Antonio Fernandez Dumont Andrea Gennaro José Ángel Gómez Ruiz Paschalina Grammatikou Tilemachos Goumperis Paolo Lenzi Aleksandra Lewandowska Ana Martin Camargo Franco Maria Neri Pietro Piffanelli Tommaso Raffaello Kyriaki Xiftou |
| author_facet | EFSA Panel on Genetically Modified Organisms (GMO) Ewen Mullins Jean‐Louis Bresson Tamas Dalmay Ian Crawford Dewhurst Michelle M. Epstein Leslie George Firbank Philippe Guerche Jan Hejatko Hanspeter Naegeli Francisco Javier Moreno Fabien Nogué Nils Rostoks Jose Juan Sánchez Serrano Giovanni Savoini Eve Veromann Fabio Veronesi Michele Ardizzone Giacomo De Sanctis Antonio Fernandez Dumont Andrea Gennaro José Ángel Gómez Ruiz Paschalina Grammatikou Tilemachos Goumperis Paolo Lenzi Aleksandra Lewandowska Ana Martin Camargo Franco Maria Neri Pietro Piffanelli Tommaso Raffaello Kyriaki Xiftou |
| author_sort | EFSA Panel on Genetically Modified Organisms (GMO) |
| collection | DOAJ |
| description | Abstract Genetically modified (GM) maize DP910521 was developed to confer resistance against certain lepidopteran insect pests as well as tolerance to glufosinate herbicide; these properties were achieved by introducing the mo‐pat, pmi and cry1B.34 expression cassettes. The molecular characterisation data and bioinformatic analyses did not identify issues requiring food/feed safety assessment. None of the identified differences in the agronomic/phenotypic and compositional characteristics tested between maize DP910521 and its conventional counterpart needs further assessment except for the levels of iron in grain, which do not raise safety and nutritional concerns. The GMO Panel does not identify safety concerns regarding the toxicity and allergenicity of the Cry1B.34, PAT and PMI proteins as expressed in maize DP910521. The GMO panel finds no evidence that the genetic modification impacts the overall safety of maize DP910521. In the context of this application, the consumption of food and feed from maize DP910521 does not represent a nutritional concern in humans and animals. The GMO Panel concludes that maize DP910521 is as safe as its conventional counterpart and non‐GM maize varieties tested, and no post‐market monitoring of food/feed is considered necessary. In the case of accidental release of maize DP910521 material into the environment, this would not raise environmental safety concerns. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of maize DP910521. The GMO Panel concludes that maize DP910521 is as safe as its conventional counterpart and the tested non‐GM maize varieties with respect to potential effects on human and animal health and the environment. |
| format | Article |
| id | doaj-art-6361e7cbe105487f87f34e474de52a2b |
| institution | DOAJ |
| issn | 1831-4732 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj-art-6361e7cbe105487f87f34e474de52a2b2025-08-20T03:10:03ZengWileyEFSA Journal1831-47322024-08-01228n/an/a10.2903/j.efsa.2024.8887Assessment of genetically modified maize DP910521 (application GMFF‐2021‐2473)EFSA Panel on Genetically Modified Organisms (GMO)Ewen MullinsJean‐Louis BressonTamas DalmayIan Crawford DewhurstMichelle M. EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoHanspeter NaegeliFrancisco Javier MorenoFabien NoguéNils RostoksJose Juan Sánchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiMichele ArdizzoneGiacomo De SanctisAntonio Fernandez DumontAndrea GennaroJosé Ángel Gómez RuizPaschalina GrammatikouTilemachos GoumperisPaolo LenziAleksandra LewandowskaAna Martin CamargoFranco Maria NeriPietro PiffanelliTommaso RaffaelloKyriaki XiftouAbstract Genetically modified (GM) maize DP910521 was developed to confer resistance against certain lepidopteran insect pests as well as tolerance to glufosinate herbicide; these properties were achieved by introducing the mo‐pat, pmi and cry1B.34 expression cassettes. The molecular characterisation data and bioinformatic analyses did not identify issues requiring food/feed safety assessment. None of the identified differences in the agronomic/phenotypic and compositional characteristics tested between maize DP910521 and its conventional counterpart needs further assessment except for the levels of iron in grain, which do not raise safety and nutritional concerns. The GMO Panel does not identify safety concerns regarding the toxicity and allergenicity of the Cry1B.34, PAT and PMI proteins as expressed in maize DP910521. The GMO panel finds no evidence that the genetic modification impacts the overall safety of maize DP910521. In the context of this application, the consumption of food and feed from maize DP910521 does not represent a nutritional concern in humans and animals. The GMO Panel concludes that maize DP910521 is as safe as its conventional counterpart and non‐GM maize varieties tested, and no post‐market monitoring of food/feed is considered necessary. In the case of accidental release of maize DP910521 material into the environment, this would not raise environmental safety concerns. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of maize DP910521. The GMO Panel concludes that maize DP910521 is as safe as its conventional counterpart and the tested non‐GM maize varieties with respect to potential effects on human and animal health and the environment.https://doi.org/10.2903/j.efsa.2024.8887Cry1B.34DP910521genetic engineeringGMimport and processingmaize (Zea mays) |
| spellingShingle | EFSA Panel on Genetically Modified Organisms (GMO) Ewen Mullins Jean‐Louis Bresson Tamas Dalmay Ian Crawford Dewhurst Michelle M. Epstein Leslie George Firbank Philippe Guerche Jan Hejatko Hanspeter Naegeli Francisco Javier Moreno Fabien Nogué Nils Rostoks Jose Juan Sánchez Serrano Giovanni Savoini Eve Veromann Fabio Veronesi Michele Ardizzone Giacomo De Sanctis Antonio Fernandez Dumont Andrea Gennaro José Ángel Gómez Ruiz Paschalina Grammatikou Tilemachos Goumperis Paolo Lenzi Aleksandra Lewandowska Ana Martin Camargo Franco Maria Neri Pietro Piffanelli Tommaso Raffaello Kyriaki Xiftou Assessment of genetically modified maize DP910521 (application GMFF‐2021‐2473) EFSA Journal Cry1B.34 DP910521 genetic engineering GM import and processing maize (Zea mays) |
| title | Assessment of genetically modified maize DP910521 (application GMFF‐2021‐2473) |
| title_full | Assessment of genetically modified maize DP910521 (application GMFF‐2021‐2473) |
| title_fullStr | Assessment of genetically modified maize DP910521 (application GMFF‐2021‐2473) |
| title_full_unstemmed | Assessment of genetically modified maize DP910521 (application GMFF‐2021‐2473) |
| title_short | Assessment of genetically modified maize DP910521 (application GMFF‐2021‐2473) |
| title_sort | assessment of genetically modified maize dp910521 application gmff 2021 2473 |
| topic | Cry1B.34 DP910521 genetic engineering GM import and processing maize (Zea mays) |
| url | https://doi.org/10.2903/j.efsa.2024.8887 |
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