The role of salivary antioxidant level in polycystic ovary syndrome women under assisted reproductive technology treatment: A case-control study
Background: Infertility is defined as the inability to conceive after 12 months of regular unprotected intercourse. Approximately 85% of infertile couples have an identifiable cause, one of the most common causes of infertility is polycystic ovary syndrome (PCOS). The reduction of antioxidant level...
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Shahid Sadoughi University of Medical Sciences
2025-02-01
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| Series: | International Journal of Reproductive BioMedicine |
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| Online Access: | https://knepublishing.com/index.php/ijrm/article/view/18063 |
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| author | Narges Gholizadeh Maryam Koopaie Ashraf Aleyasin Atousa Mortazavi Milani Marziyeh Aghahosseini Mohammad Javad Kharrazifard Mohadeseh Bahmaee |
| author_facet | Narges Gholizadeh Maryam Koopaie Ashraf Aleyasin Atousa Mortazavi Milani Marziyeh Aghahosseini Mohammad Javad Kharrazifard Mohadeseh Bahmaee |
| author_sort | Narges Gholizadeh |
| collection | DOAJ |
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Background: Infertility is defined as the inability to conceive after 12 months of regular unprotected intercourse. Approximately 85% of infertile couples have an identifiable cause, one of the most common causes of infertility is polycystic ovary syndrome (PCOS). The reduction of antioxidant levels in serum and follicular fluid in infertile women compared to healthy women shows the importance of further studying these markers.
Objective: To study salivary and serum antioxidant levels in PCOS participants under assisted reproductive technology.
Materials and Methods: This case-control study was conducted on 80 women in 2 groups including normal participants as control and PCOS groups (n = 40/each). Serum and salivary antioxidant levels such as saliva superoxide dismutase (SOD), saliva anti-Müllerian hormone (AMH), serum SOD, serum total oxidant status, and serum AMH were measured.
Results: The average age of participants was 31.6 ± 5.4 yr. In both the saliva and serum, antioxidant levels differed significantly between the PCOS and control groups. Key findings showed that the PCOS group had different antioxidant levels and higher serum AMH levels compared to the control group, with all differences being statistically significant (p < 0.05).
Conclusion: Our finding underscored that saliva antioxidant levels, especially SOD, are a good marker for PCOS diagnosis. It is noninvasive, can easily be performed by the participants, and can be collected in various settings without specialized equipment.
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| format | Article |
| id | doaj-art-636151b01d0447028ed911e8339707f1 |
| institution | Kabale University |
| issn | 2476-4108 2476-3772 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | International Journal of Reproductive BioMedicine |
| spelling | doaj-art-636151b01d0447028ed911e8339707f12025-02-08T12:09:25ZengShahid Sadoughi University of Medical SciencesInternational Journal of Reproductive BioMedicine2476-41082476-37722025-02-01221210.18502/ijrm.v22i12.18063The role of salivary antioxidant level in polycystic ovary syndrome women under assisted reproductive technology treatment: A case-control studyNarges Gholizadeh0Maryam Koopaie1Ashraf Aleyasin2Atousa Mortazavi Milani3Marziyeh Aghahosseini4Mohammad Javad Kharrazifard5Mohadeseh Bahmaee6Department of Oral and Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.Department of Oral and Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.Department of Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranClinical Research Development Unit of Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.Department of Obstetrics and Gynecology and Female Infertility Unit, Tehran University of Medical Sciences, Tehran, Iran.Department of Epidemiology and Biostatistics, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Background: Infertility is defined as the inability to conceive after 12 months of regular unprotected intercourse. Approximately 85% of infertile couples have an identifiable cause, one of the most common causes of infertility is polycystic ovary syndrome (PCOS). The reduction of antioxidant levels in serum and follicular fluid in infertile women compared to healthy women shows the importance of further studying these markers. Objective: To study salivary and serum antioxidant levels in PCOS participants under assisted reproductive technology. Materials and Methods: This case-control study was conducted on 80 women in 2 groups including normal participants as control and PCOS groups (n = 40/each). Serum and salivary antioxidant levels such as saliva superoxide dismutase (SOD), saliva anti-Müllerian hormone (AMH), serum SOD, serum total oxidant status, and serum AMH were measured. Results: The average age of participants was 31.6 ± 5.4 yr. In both the saliva and serum, antioxidant levels differed significantly between the PCOS and control groups. Key findings showed that the PCOS group had different antioxidant levels and higher serum AMH levels compared to the control group, with all differences being statistically significant (p < 0.05). Conclusion: Our finding underscored that saliva antioxidant levels, especially SOD, are a good marker for PCOS diagnosis. It is noninvasive, can easily be performed by the participants, and can be collected in various settings without specialized equipment. https://knepublishing.com/index.php/ijrm/article/view/18063Infertility, Saliva, Antioxidant, Polycystic ovary syndrome, Diagnosis. |
| spellingShingle | Narges Gholizadeh Maryam Koopaie Ashraf Aleyasin Atousa Mortazavi Milani Marziyeh Aghahosseini Mohammad Javad Kharrazifard Mohadeseh Bahmaee The role of salivary antioxidant level in polycystic ovary syndrome women under assisted reproductive technology treatment: A case-control study International Journal of Reproductive BioMedicine Infertility, Saliva, Antioxidant, Polycystic ovary syndrome, Diagnosis. |
| title | The role of salivary antioxidant level in polycystic ovary syndrome women under assisted reproductive technology treatment: A case-control study |
| title_full | The role of salivary antioxidant level in polycystic ovary syndrome women under assisted reproductive technology treatment: A case-control study |
| title_fullStr | The role of salivary antioxidant level in polycystic ovary syndrome women under assisted reproductive technology treatment: A case-control study |
| title_full_unstemmed | The role of salivary antioxidant level in polycystic ovary syndrome women under assisted reproductive technology treatment: A case-control study |
| title_short | The role of salivary antioxidant level in polycystic ovary syndrome women under assisted reproductive technology treatment: A case-control study |
| title_sort | role of salivary antioxidant level in polycystic ovary syndrome women under assisted reproductive technology treatment a case control study |
| topic | Infertility, Saliva, Antioxidant, Polycystic ovary syndrome, Diagnosis. |
| url | https://knepublishing.com/index.php/ijrm/article/view/18063 |
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