A Breast Cancer Polygenic Risk Score Validation in 15,490 Brazilians Using Exome Sequencing

A Breast Cancer Polygenic Risk Score Validation in 15,490 Brazilians Using Exome Sequencing

<b>Background/Objectives</b>: Brazil has a highly admixed population. Polygenic risk scores (PRSs) have mostly been developed from European population studies, and their application to other populations is challenging. To assess the use of PRS for breast cancer (BC) risk in Brazil, we ev...

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Main Authors: Flávia Eichemberger Rius, Rodrigo Santa Cruz Guindalini, Danilo Viana, Júlia Salomão, Laila Gallo, Renata Freitas, Cláudia Bertolacini, Lucas Taniguti, Danilo Imparato, Flávia Antunes, Gabriel Sousa, Renan Achjian, Eric Fukuyama, Cleandra Gregório, Iuri Ventura, Juliana Gomes, Nathália Taniguti, Simone Maistro, José Eduardo Krieger, Yonglan Zheng, Dezheng Huo, Olufunmilayo I. Olopade, Maria Aparecida Azevedo Koike Folgueira, David Schlesinger
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Diagnostics
Subjects:
polygenic risk score (PRS)
breast cancer
admixed population
cancer genetics
next-generation sequencing (NGS)
precision medicine
Online Access:https://www.mdpi.com/2075-4418/15/9/1098
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