Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and Obesity
Diabetes and obesity are chronic conditions associated with elevated oxidative/inflammatory activities with a continuum of tissue insults leading to more severe cardiometabolic and renal complications including myocardial infarction and end-stage-renal damage. A common denominator of these chronic c...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/359732 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567451655602176 |
|---|---|
| author | Joseph Fomusi Ndisang |
| author_facet | Joseph Fomusi Ndisang |
| author_sort | Joseph Fomusi Ndisang |
| collection | DOAJ |
| description | Diabetes and obesity are chronic conditions associated with elevated oxidative/inflammatory activities with a continuum of tissue insults leading to more severe cardiometabolic and renal complications including myocardial infarction and end-stage-renal damage. A common denominator of these chronic conditions is the enhanced the levels of cytokines like tumour necrosis factor-alpha (TNF-α), interleukin (IL-6), IL-1β and resistin, which in turn activates the c-Jun-N-terminal kinase (JNK) and NF-κB pathways, creating a vicious cycle that exacerbates insulin resistance, type-2 diabetes and related complications. Emerging evidence indicates that heme oxygenase (HO) inducers are endowed with potent anti-diabetic and insulin sensitizing effects besides their ability to suppress immune/inflammatory response. Importantly, the HO system abates inflammation through several mechanisms including the suppression of macrophage-infiltration and abrogation of oxidative/inflammatory transcription factors like NF-κB, JNK and activating protein-1. This review highlights the mechanisms by which the HO system potentiates insulin signalling, with particular emphasis on HO-mediated suppression of oxidative and inflammatory insults. The HO system could be explored in the search for novel remedies against cardiometabolic diseases and their complications. |
| format | Article |
| id | doaj-art-6358b5550f774ec4bda50860862837fd |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-6358b5550f774ec4bda50860862837fd2025-02-03T01:01:33ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/359732359732Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and ObesityJoseph Fomusi Ndisang0Department of Physiology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, S7N 5E5, CanadaDiabetes and obesity are chronic conditions associated with elevated oxidative/inflammatory activities with a continuum of tissue insults leading to more severe cardiometabolic and renal complications including myocardial infarction and end-stage-renal damage. A common denominator of these chronic conditions is the enhanced the levels of cytokines like tumour necrosis factor-alpha (TNF-α), interleukin (IL-6), IL-1β and resistin, which in turn activates the c-Jun-N-terminal kinase (JNK) and NF-κB pathways, creating a vicious cycle that exacerbates insulin resistance, type-2 diabetes and related complications. Emerging evidence indicates that heme oxygenase (HO) inducers are endowed with potent anti-diabetic and insulin sensitizing effects besides their ability to suppress immune/inflammatory response. Importantly, the HO system abates inflammation through several mechanisms including the suppression of macrophage-infiltration and abrogation of oxidative/inflammatory transcription factors like NF-κB, JNK and activating protein-1. This review highlights the mechanisms by which the HO system potentiates insulin signalling, with particular emphasis on HO-mediated suppression of oxidative and inflammatory insults. The HO system could be explored in the search for novel remedies against cardiometabolic diseases and their complications.http://dx.doi.org/10.1155/2010/359732 |
| spellingShingle | Joseph Fomusi Ndisang Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and Obesity Mediators of Inflammation |
| title | Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and Obesity |
| title_full | Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and Obesity |
| title_fullStr | Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and Obesity |
| title_full_unstemmed | Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and Obesity |
| title_short | Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and Obesity |
| title_sort | role of heme oxygenase in inflammation insulin signalling diabetes and obesity |
| url | http://dx.doi.org/10.1155/2010/359732 |
| work_keys_str_mv | AT josephfomusindisang roleofhemeoxygenaseininflammationinsulinsignallingdiabetesandobesity |