Calcineurin-mediated regulation of growth-associated protein 43 is essential for neurite and synapse formation and protects against α-synuclein-induced degeneration

Calcineurin-mediated regulation of growth-associated protein 43 is essential for neurite and synapse formation and protects against α-synuclein-induced degeneration

IntroductionElevated calcium (Ca2+) levels and hyperactivation of the Ca2+-dependent phosphatase calcineurin are key factors in α-synuclein (α-syn) pathobiology in Dementia with Lewy Bodies and Parkinson’s Disease (PD). Calcineurin activity can be inhibited by FK506, an FDA-approved compound. Our pr...

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Bibliographic Details
Main Authors: Ekaterina Grebenik, Sofia Zaichick, Gabriela Caraveo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
α-synuclein
calcineurin
FK506
neuroprotection
GAP-43
neurite branching
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1566465/full
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