Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations
Allogenic hematopoietic progenitor cell transplantation (allo-HSCT) is an established treatment for many diseases. Stem cells may be obtained from different sources: mobilized peripheral blood stem cells, bone marrow, and umbilical cord blood. The progress in transplantation procedures, the establis...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/5250790 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559834995621888 |
|---|---|
| author | Irene Riezzo Natascha Pascale Raffaele La Russa Arcangelo Liso Monica Salerno Emanuela Turillazzi |
| author_facet | Irene Riezzo Natascha Pascale Raffaele La Russa Arcangelo Liso Monica Salerno Emanuela Turillazzi |
| author_sort | Irene Riezzo |
| collection | DOAJ |
| description | Allogenic hematopoietic progenitor cell transplantation (allo-HSCT) is an established treatment for many diseases. Stem cells may be obtained from different sources: mobilized peripheral blood stem cells, bone marrow, and umbilical cord blood. The progress in transplantation procedures, the establishment of experienced transplant centres, and the creation of unrelated adult donor registries and cord blood banks gave those without an human leucocyte antigen- (HLA-) identical sibling donor the opportunity to find a donor and cord blood units worldwide. HSCT imposes operative cautions so that the entire donation/transplantation procedure is safe for both donors and recipients; it carries with it significant clinical, moral, and ethical concerns, mostly when donors are minors. The following points have been stressed: the donation should be excluded when excessive risks for the donor are reasonable, donors must receive an accurate information regarding eventual adverse events and health burden for the donors themselves, a valid consent is required, and the recipient’s risks must be outweighed by the expected benefits. The issue of conflict of interest, when the same physician has the responsibility for both donor selection and recipient care, is highlighted as well as the need of an adequate insurance protection for all the parties involved. |
| format | Article |
| id | doaj-art-6354536fbe054008a504e13ab7415470 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-6354536fbe054008a504e13ab74154702025-02-03T01:29:02ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/52507905250790Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical ConsiderationsIrene Riezzo0Natascha Pascale1Raffaele La Russa2Arcangelo Liso3Monica Salerno4Emanuela Turillazzi5Institute of Legal Medicine, Department of Clinical and Experimental Medicine, University of Foggia, Ospedale “Colonnello D'Avanzo”, Viale Degli Aviatori, 1, 71122 Foggia, ItalyInstitute of Legal Medicine, Department of Clinical and Experimental Medicine, University of Foggia, Ospedale “Colonnello D'Avanzo”, Viale Degli Aviatori, 1, 71122 Foggia, ItalyIstituto Clinico-Scientifico Malzoni, 83100 Avellino, ItalyInstitute of Hematology, Department of Medical and Surgical Sciences, University of Foggia, Viale Pinto 1, 71122 Foggia, ItalyInstitute of Legal Medicine, Department of Clinical and Experimental Medicine, University of Foggia, Ospedale “Colonnello D'Avanzo”, Viale Degli Aviatori, 1, 71122 Foggia, ItalyInstitute of Legal Medicine, Department of Clinical and Experimental Medicine, University of Foggia, Ospedale “Colonnello D'Avanzo”, Viale Degli Aviatori, 1, 71122 Foggia, ItalyAllogenic hematopoietic progenitor cell transplantation (allo-HSCT) is an established treatment for many diseases. Stem cells may be obtained from different sources: mobilized peripheral blood stem cells, bone marrow, and umbilical cord blood. The progress in transplantation procedures, the establishment of experienced transplant centres, and the creation of unrelated adult donor registries and cord blood banks gave those without an human leucocyte antigen- (HLA-) identical sibling donor the opportunity to find a donor and cord blood units worldwide. HSCT imposes operative cautions so that the entire donation/transplantation procedure is safe for both donors and recipients; it carries with it significant clinical, moral, and ethical concerns, mostly when donors are minors. The following points have been stressed: the donation should be excluded when excessive risks for the donor are reasonable, donors must receive an accurate information regarding eventual adverse events and health burden for the donors themselves, a valid consent is required, and the recipient’s risks must be outweighed by the expected benefits. The issue of conflict of interest, when the same physician has the responsibility for both donor selection and recipient care, is highlighted as well as the need of an adequate insurance protection for all the parties involved.http://dx.doi.org/10.1155/2017/5250790 |
| spellingShingle | Irene Riezzo Natascha Pascale Raffaele La Russa Arcangelo Liso Monica Salerno Emanuela Turillazzi Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations Stem Cells International |
| title | Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations |
| title_full | Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations |
| title_fullStr | Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations |
| title_full_unstemmed | Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations |
| title_short | Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations |
| title_sort | donor selection for allogenic hemopoietic stem cell transplantation clinical and ethical considerations |
| url | http://dx.doi.org/10.1155/2017/5250790 |
| work_keys_str_mv | AT ireneriezzo donorselectionforallogenichemopoieticstemcelltransplantationclinicalandethicalconsiderations AT nataschapascale donorselectionforallogenichemopoieticstemcelltransplantationclinicalandethicalconsiderations AT raffaelelarussa donorselectionforallogenichemopoieticstemcelltransplantationclinicalandethicalconsiderations AT arcangeloliso donorselectionforallogenichemopoieticstemcelltransplantationclinicalandethicalconsiderations AT monicasalerno donorselectionforallogenichemopoieticstemcelltransplantationclinicalandethicalconsiderations AT emanuelaturillazzi donorselectionforallogenichemopoieticstemcelltransplantationclinicalandethicalconsiderations |