Genome‐wide association study of tuberculosis in the western Chinese Han and Tibetan population
Abstract Tuberculosis (TB) remains a serious global public health threat. Accumulated evidence has demonstrated that human susceptibility to TB has a strong genetic basis. And different susceptibility single nucleotide polymorphisms (SNP) have been reported in different studies. To gain greater insi...
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | MedComm |
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| Online Access: | https://doi.org/10.1002/mco2.250 |
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| author | Hao Bai Mengyuan Song Shikun Lei Lin Jiao Xuejiao Hu Tao Wu Jiajia Song Tangyuheng Liu Wu Peng Zhenzhen Zhao Zirui Meng Binwu Ying |
| author_facet | Hao Bai Mengyuan Song Shikun Lei Lin Jiao Xuejiao Hu Tao Wu Jiajia Song Tangyuheng Liu Wu Peng Zhenzhen Zhao Zirui Meng Binwu Ying |
| author_sort | Hao Bai |
| collection | DOAJ |
| description | Abstract Tuberculosis (TB) remains a serious global public health threat. Accumulated evidence has demonstrated that human susceptibility to TB has a strong genetic basis. And different susceptibility single nucleotide polymorphisms (SNP) have been reported in different studies. To gain greater insight into the host susceptibility to TB, we perform a two‐stage genome‐wide association study to identify the susceptible loci of TB. In the discovery stage, 3116 (1532 TB patients and 1584 healthy controls) and 439 (211 TB patients and 228 healthy controls) individuals were genome‐wide genotyped from a western Chinese Han and Tibetan population, respectively. Based on the additive genetic model, we discovered 14 and three independent loci that had potential associations with TB susceptibility in the Chinese Han and Tibetan populations, respectively (p < 1 × 10−5). Furthermore, we conducted an imputation‐based meta‐analysis on another two East Asia cohorts to replicate our findings. We identified one independent locus harbored by the human leukocyte antigen (HLA) class II genes that was genome‐wide significantly associated with TB (lead SNP rs111875628 with a p‐value of 2.20 × 10−9). Our findings suggest a novel mechanism of the interaction with the HLA class II genes and reinforce the importance of the HLA class II alleles in response to TB. |
| format | Article |
| id | doaj-art-634f50afb18e4f11a2710c850a86eb3f |
| institution | Kabale University |
| issn | 2688-2663 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj-art-634f50afb18e4f11a2710c850a86eb3f2025-01-24T05:36:29ZengWileyMedComm2688-26632023-04-0142n/an/a10.1002/mco2.250Genome‐wide association study of tuberculosis in the western Chinese Han and Tibetan populationHao Bai0Mengyuan Song1Shikun Lei2Lin Jiao3Xuejiao Hu4Tao Wu5Jiajia Song6Tangyuheng Liu7Wu Peng8Zhenzhen Zhao9Zirui Meng10Binwu Ying11Department of Laboratory Medicine West China Hospital Sichuan University Chengdu P. R. ChinaDepartment of Laboratory Medicine West China Hospital Sichuan University Chengdu P. R. ChinaState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Chengdu P. R. ChinaDepartment of Laboratory Medicine West China Hospital Sichuan University Chengdu P. R. ChinaDivision of Laboratory Medicine Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou P. R. ChinaDepartment of Laboratory Medicine West China Hospital Sichuan University Chengdu P. R. ChinaDepartment of Laboratory Medicine West China Hospital Sichuan University Chengdu P. R. ChinaDepartment of Laboratory Medicine West China Hospital Sichuan University Chengdu P. R. ChinaDepartment of Laboratory Medicine West China Hospital Sichuan University Chengdu P. R. ChinaDepartment of Laboratory Medicine West China Hospital Sichuan University Chengdu P. R. ChinaDepartment of Laboratory Medicine West China Hospital Sichuan University Chengdu P. R. ChinaDepartment of Laboratory Medicine West China Hospital Sichuan University Chengdu P. R. ChinaAbstract Tuberculosis (TB) remains a serious global public health threat. Accumulated evidence has demonstrated that human susceptibility to TB has a strong genetic basis. And different susceptibility single nucleotide polymorphisms (SNP) have been reported in different studies. To gain greater insight into the host susceptibility to TB, we perform a two‐stage genome‐wide association study to identify the susceptible loci of TB. In the discovery stage, 3116 (1532 TB patients and 1584 healthy controls) and 439 (211 TB patients and 228 healthy controls) individuals were genome‐wide genotyped from a western Chinese Han and Tibetan population, respectively. Based on the additive genetic model, we discovered 14 and three independent loci that had potential associations with TB susceptibility in the Chinese Han and Tibetan populations, respectively (p < 1 × 10−5). Furthermore, we conducted an imputation‐based meta‐analysis on another two East Asia cohorts to replicate our findings. We identified one independent locus harbored by the human leukocyte antigen (HLA) class II genes that was genome‐wide significantly associated with TB (lead SNP rs111875628 with a p‐value of 2.20 × 10−9). Our findings suggest a novel mechanism of the interaction with the HLA class II genes and reinforce the importance of the HLA class II alleles in response to TB.https://doi.org/10.1002/mco2.250genome‐wide association studyhuman leukocyte antigensusceptibilitytuberculosis |
| spellingShingle | Hao Bai Mengyuan Song Shikun Lei Lin Jiao Xuejiao Hu Tao Wu Jiajia Song Tangyuheng Liu Wu Peng Zhenzhen Zhao Zirui Meng Binwu Ying Genome‐wide association study of tuberculosis in the western Chinese Han and Tibetan population MedComm genome‐wide association study human leukocyte antigen susceptibility tuberculosis |
| title | Genome‐wide association study of tuberculosis in the western Chinese Han and Tibetan population |
| title_full | Genome‐wide association study of tuberculosis in the western Chinese Han and Tibetan population |
| title_fullStr | Genome‐wide association study of tuberculosis in the western Chinese Han and Tibetan population |
| title_full_unstemmed | Genome‐wide association study of tuberculosis in the western Chinese Han and Tibetan population |
| title_short | Genome‐wide association study of tuberculosis in the western Chinese Han and Tibetan population |
| title_sort | genome wide association study of tuberculosis in the western chinese han and tibetan population |
| topic | genome‐wide association study human leukocyte antigen susceptibility tuberculosis |
| url | https://doi.org/10.1002/mco2.250 |
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