Screening for Polymorphism, Cyclodextrin Complexation, and Co-Crystallization of the Non-Steroidal Anti-Inflammatory Drug Fenbufen: Isolation and Characterization of a Co-Crystal and an Ionic Co-Crystal of the API with a Common Coformer

Screening for Polymorphism, Cyclodextrin Complexation, and Co-Crystallization of the Non-Steroidal Anti-Inflammatory Drug Fenbufen: Isolation and Characterization of a Co-Crystal and an Ionic Co-Crystal of the API with a Common Coformer

<b>Background/Objectives</b>: Increasing the solid-state landscape of an active pharmaceutical ingredient (API) by generating new crystalline forms (e.g., polymorphs, cyclodextrin (CD) inclusion complexes, co-crystals, and salts) can yield products with significantly enhanced biopharmace...

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Bibliographic Details
Main Authors: Hannah M. Frösler, Neo Refiloe Mancapa, Laura Catenacci, Milena Sorrenti, Maria Cristina Bonferoni, Mino R. Caira
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceutics
Subjects:
fenbufen
isonicotinamide
co-crystal
ionic co-crystal
cyclodextrins
thermal analysis
Online Access:https://www.mdpi.com/1999-4923/17/7/842
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