Mechanistic insights curcumin’s anti-inflammatory in pancreatic cancer: experimental and computational evidence implicating IL1B interference via IL10RA upregulation and NLRP3/TLR3 downregulation

Mechanistic insights curcumin’s anti-inflammatory in pancreatic cancer: experimental and computational evidence implicating IL1B interference via IL10RA upregulation and NLRP3/TLR3 downregulation

PurposePancreatic cancer is a highly aggressive malignancy characterised by a complex tumour microenvironment and chronic inflammation. Studies found curcumin inhibited with inflammatory responses and tumour proliferation by interfering with production and activation of pro-inflammatory factors. Thi...

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Bibliographic Details
Main Authors: Jun-Feng Cao, Kuan Hang, Hao Zhang, Qingjie Xia, Xiao Zhang, Jie Men, Jin Tian, Zengliang Xia, Dunshui Liao, Kezhou Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
curcumin
pancreatic cancer
machine learning
transcriptome sequencing
cellular experiments
computer simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1601908/full
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