C-kit-negative Extragastrointestinal Stromal Tumor Originating in the Mesentery Misdiagnosed as an Ovarian Tumor before Surgery
Gastrointestinal stromal tumors (GISTs) are rare digestive system malignancies with extragastrointestinal stromal tumors (EGISTs) being even less. Diagnosing GISTs usually requires the identification of c-kit (CD117) expression by immunohistochemical staining. A 53-year-old woman complaining of dysp...
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Korean College of Helicobacter and Upper Gastrointestinal Research
2021-06-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
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| Online Access: | http://www.helicojournal.org/upload/pdf/kjhugr-2020-0061.pdf |
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| author | Jongryeul Lim Myong Ki Baeg Sangjeong Ahn Man Ho Ha Sun-Hye Ko Hyuki Kwon Jaeho Han |
| author_facet | Jongryeul Lim Myong Ki Baeg Sangjeong Ahn Man Ho Ha Sun-Hye Ko Hyuki Kwon Jaeho Han |
| author_sort | Jongryeul Lim |
| collection | DOAJ |
| description | Gastrointestinal stromal tumors (GISTs) are rare digestive system malignancies with extragastrointestinal stromal tumors (EGISTs) being even less. Diagnosing GISTs usually requires the identification of c-kit (CD117) expression by immunohistochemical staining. A 53-year-old woman complaining of dyspepsia was referred for the evaluation of a 1.5-cm extrinsic compression at the greater curvature of the proximal antrum. EUS revealed a multiseptated mass with positive Doppler findings. Abdominal CT showed that she harbored a large, 20-cm mass in her abdominal cavity, most likely arising from the right ovary. Surgery revealed a hypervascular tumor arising from the mesentery and attached to the gastric lesser curvature. Pathological examination revealed negativity for c-kit, but positivity for the protein “Discovered on GIST-1” (DOG1), confirming the EGIST diagnosis. Herein, we report this rare case of a c-kit-negative EGIST originating in the mesentery, which was diagnosed based on staining for DOG1. |
| format | Article |
| id | doaj-art-6345f4401ab14c45bcb9ea462e8d748a |
| institution | Kabale University |
| issn | 1738-3331 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | Korean College of Helicobacter and Upper Gastrointestinal Research |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj-art-6345f4401ab14c45bcb9ea462e8d748a2025-08-20T03:33:46ZengKorean College of Helicobacter and Upper Gastrointestinal ResearchThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312021-06-0121215616010.7704/kjhugr.2020.0061669C-kit-negative Extragastrointestinal Stromal Tumor Originating in the Mesentery Misdiagnosed as an Ovarian Tumor before SurgeryJongryeul Lim0Myong Ki Baeg1Sangjeong Ahn2Man Ho Ha3Sun-Hye Ko4Hyuki Kwon5Jaeho Han6 Division of Gastroenterology, Department of Internal Medicine, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea Division of Gastroenterology, Department of Internal Medicine, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea Division of Gastroenterology, Department of Pathology, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea Division of Gastroenterology, Department of Surgery, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea Division of Hematology, Department of Internal Medicine, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea Division of Gastroenterology, Department of Internal Medicine, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea Division of Gastroenterology, Department of Internal Medicine, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon, KoreaGastrointestinal stromal tumors (GISTs) are rare digestive system malignancies with extragastrointestinal stromal tumors (EGISTs) being even less. Diagnosing GISTs usually requires the identification of c-kit (CD117) expression by immunohistochemical staining. A 53-year-old woman complaining of dyspepsia was referred for the evaluation of a 1.5-cm extrinsic compression at the greater curvature of the proximal antrum. EUS revealed a multiseptated mass with positive Doppler findings. Abdominal CT showed that she harbored a large, 20-cm mass in her abdominal cavity, most likely arising from the right ovary. Surgery revealed a hypervascular tumor arising from the mesentery and attached to the gastric lesser curvature. Pathological examination revealed negativity for c-kit, but positivity for the protein “Discovered on GIST-1” (DOG1), confirming the EGIST diagnosis. Herein, we report this rare case of a c-kit-negative EGIST originating in the mesentery, which was diagnosed based on staining for DOG1.http://www.helicojournal.org/upload/pdf/kjhugr-2020-0061.pdfc-kit proteindog-1 proteingastrointestinal stromal tumormesentery |
| spellingShingle | Jongryeul Lim Myong Ki Baeg Sangjeong Ahn Man Ho Ha Sun-Hye Ko Hyuki Kwon Jaeho Han C-kit-negative Extragastrointestinal Stromal Tumor Originating in the Mesentery Misdiagnosed as an Ovarian Tumor before Surgery The Korean Journal of Helicobacter and Upper Gastrointestinal Research c-kit protein dog-1 protein gastrointestinal stromal tumor mesentery |
| title | C-kit-negative Extragastrointestinal Stromal Tumor Originating in the Mesentery Misdiagnosed as an Ovarian Tumor before Surgery |
| title_full | C-kit-negative Extragastrointestinal Stromal Tumor Originating in the Mesentery Misdiagnosed as an Ovarian Tumor before Surgery |
| title_fullStr | C-kit-negative Extragastrointestinal Stromal Tumor Originating in the Mesentery Misdiagnosed as an Ovarian Tumor before Surgery |
| title_full_unstemmed | C-kit-negative Extragastrointestinal Stromal Tumor Originating in the Mesentery Misdiagnosed as an Ovarian Tumor before Surgery |
| title_short | C-kit-negative Extragastrointestinal Stromal Tumor Originating in the Mesentery Misdiagnosed as an Ovarian Tumor before Surgery |
| title_sort | c kit negative extragastrointestinal stromal tumor originating in the mesentery misdiagnosed as an ovarian tumor before surgery |
| topic | c-kit protein dog-1 protein gastrointestinal stromal tumor mesentery |
| url | http://www.helicojournal.org/upload/pdf/kjhugr-2020-0061.pdf |
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