Effectiveness of mucoactives (carbocisteine and hypertonic saline) in addition to usual airway clearance management with usual airway clearance management alone in acute respiratory failure (MARCH): study protocol for a multi-centre 2x2 factorial, randomised, controlled, open-label, Phase 3, pragmatic, clinical and cost-effectiveness trial with internal pilot [version 1; peer review: 2 approved]

Background Usual airway clearance management in critically ill patients with acute respiratory failure includes suctioning, humidification, use of isotonic saline, and respiratory physiotherapy techniques. Escalation to use of mucoactives occurs when secretions are difficult to clear. Use of mucoact...

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Main Authors:	Mike Clarke, Marc Chikhani, Cliona McDowell, Ranjit Lall, Michael McKelvey, Margaret McFarland, Brenda O'Neill, Cecilia O'Kane, Murali Shyamsundar, Gavin Perkins, Clifford C Taggart, Gordon Sturmey, Barry Williams, John Warburton, Paul Dark, Bronwen Connolly, Ashley Agus, Naomi Dickson, Mark Borthwick, Bronagh Blackwood, Daniel F McAuley, Christina Campbell, Judy Bradley
Format:	Article
Language:	English
Published:	F1000 Research Ltd 2025-04-01
Series:	NIHR Open Research
Subjects:	Acute respiratory failure critical illness randomised controlled trial factorial carbocisteine hypertonic saline eng
Online Access:	https://openresearch.nihr.ac.uk/articles/5-30/v1
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