Water and chloride as allosteric inhibitors in WNK kinase osmosensing

Water and chloride as allosteric inhibitors in WNK kinase osmosensing

Osmotic stress and chloride regulate the autophosphorylation and activity of the WNK1 and WNK3 kinase domains. The kinase domain of unphosphorylated WNK1 (uWNK1) is an asymmetric dimer possessing water molecules conserved in multiple uWNK1 crystal structures. Conserved waters are present in two netw...

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Bibliographic Details
Main Authors: Liliana R Teixeira, Radha Akella, John M Humphreys, Haixia He, Elizabeth J Goldsmith
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-11-01
Series:eLife
Subjects:
water
osmosensor
WNK1
WNK3
chloride ion
crystallography
Online Access:https://elifesciences.org/articles/88224
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