Trichomonas vaginalis extracellular vesicles activate the NLRP3 inflammasome and TLR3-mediated inflammatory cascades in host cells.

Trichomonas vaginalis extracellular vesicles activate the NLRP3 inflammasome and TLR3-mediated inflammatory cascades in host cells.

Trichomonas vaginalis (TV) is a flagellated parasite that causes trichomoniasis, the most common non-viral sexually transmitted infection (STI), with over 275 million cases annually. TV has been shown to secrete extracellular vesicles (TV-EVs) to regulate intercellular communication between parasite...

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Main Authors: Ching-Yun Huang, Shu-Fang Chiu, Lichieh Julie Chu, Yuan-Ming Yeh, Po-Jung Huang, Kuo-Lun Lan, Yu-Ling Tsai, Ching-Chun Liu, Chien-Fu F Chen, Wei-Ning Lin, Kuo-Yang Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013216
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