Invisible Engines of Resistance: How Global Inequities Drive Antimicrobial Failure
Antimicrobial resistance (AMR) is considered a global healthcare emergency in the 21st century. Although the evolution of microorganisms through Darwinian mechanisms and antibiotic misuse are established drivers, the structural socioeconomic factors of AMR remain insufficiently explored. This review...
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MDPI AG
2025-06-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/14/7/659 |
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| author | Selim Mehmet Eke Arnold Cua |
| author_facet | Selim Mehmet Eke Arnold Cua |
| author_sort | Selim Mehmet Eke |
| collection | DOAJ |
| description | Antimicrobial resistance (AMR) is considered a global healthcare emergency in the 21st century. Although the evolution of microorganisms through Darwinian mechanisms and antibiotic misuse are established drivers, the structural socioeconomic factors of AMR remain insufficiently explored. This review takes on an analytical perspective, drawing upon a wide spectrum of evidence to examine the extent to which socioeconomic factors contribute to the global proliferation of AMR, with an emphasis on low- and middle-income countries (LMICs). The analytical review at hand was carried out through a search for relevant articles and reviews on PubMed, Google Scholar, the Centers for Disease Control and Prevention, and the World Health Organization database using combinations of the keywords “antimicrobial resistance,” “socioeconomic factors,” “low- and middle-income countries,” “surveillance,” “healthcare access,” and “agriculture.” Preference was given to systematic reviews, high-impact primary studies, and policy documents published in peer-reviewed journals or by reputable global health organizations. Our analysis identifies a complex interplay of systemic vulnerabilities that accelerate AMR in resource-limited settings. A lack of regulatory frameworks regarding non-prescription antibiotic use enables the proliferation of multi-drug-resistant microorganisms. Low sewer connectivity facilitates the environmental dissemination of resistance genes. Proper antibiotic selection is hindered by subpar healthcare systems and limited diagnostic capabilities to deliver appropriate treatment. Additionally, gender disparities, forced migration, and climate-driven zoonotic transmission compound the burden. During the COVID-19 pandemic, antimicrobial misuse surged, further amplifying resistance trends. AMR is not solely a biological phenomenon, but a manifestation of global inequity. Mitigation requires a transformation of policy directed toward a “One Health” strategy that incorporates socioeconomic, environmental, and health system reforms. Strengthening surveillance, investing in infrastructure, regulating pharmaceutical practices, and promoting health equity are essential to curb the rising tide of resistance. |
| format | Article |
| id | doaj-art-633ee2c13a7945619a6f8a6ab62c1912 |
| institution | DOAJ |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-633ee2c13a7945619a6f8a6ab62c19122025-08-20T03:13:41ZengMDPI AGAntibiotics2079-63822025-06-0114765910.3390/antibiotics14070659Invisible Engines of Resistance: How Global Inequities Drive Antimicrobial FailureSelim Mehmet Eke0Arnold Cua1Interlake High School, Bellevue, WA 98008, USAMultiCare Health System Inc., MultiCare Infectious Disease Specialists, Auburn, WA 98001, USAAntimicrobial resistance (AMR) is considered a global healthcare emergency in the 21st century. Although the evolution of microorganisms through Darwinian mechanisms and antibiotic misuse are established drivers, the structural socioeconomic factors of AMR remain insufficiently explored. This review takes on an analytical perspective, drawing upon a wide spectrum of evidence to examine the extent to which socioeconomic factors contribute to the global proliferation of AMR, with an emphasis on low- and middle-income countries (LMICs). The analytical review at hand was carried out through a search for relevant articles and reviews on PubMed, Google Scholar, the Centers for Disease Control and Prevention, and the World Health Organization database using combinations of the keywords “antimicrobial resistance,” “socioeconomic factors,” “low- and middle-income countries,” “surveillance,” “healthcare access,” and “agriculture.” Preference was given to systematic reviews, high-impact primary studies, and policy documents published in peer-reviewed journals or by reputable global health organizations. Our analysis identifies a complex interplay of systemic vulnerabilities that accelerate AMR in resource-limited settings. A lack of regulatory frameworks regarding non-prescription antibiotic use enables the proliferation of multi-drug-resistant microorganisms. Low sewer connectivity facilitates the environmental dissemination of resistance genes. Proper antibiotic selection is hindered by subpar healthcare systems and limited diagnostic capabilities to deliver appropriate treatment. Additionally, gender disparities, forced migration, and climate-driven zoonotic transmission compound the burden. During the COVID-19 pandemic, antimicrobial misuse surged, further amplifying resistance trends. AMR is not solely a biological phenomenon, but a manifestation of global inequity. Mitigation requires a transformation of policy directed toward a “One Health” strategy that incorporates socioeconomic, environmental, and health system reforms. Strengthening surveillance, investing in infrastructure, regulating pharmaceutical practices, and promoting health equity are essential to curb the rising tide of resistance.https://www.mdpi.com/2079-6382/14/7/659antimicrobial resistancesocioeconomic inequitiesantibioticsresistance genesglobal health |
| spellingShingle | Selim Mehmet Eke Arnold Cua Invisible Engines of Resistance: How Global Inequities Drive Antimicrobial Failure Antibiotics antimicrobial resistance socioeconomic inequities antibiotics resistance genes global health |
| title | Invisible Engines of Resistance: How Global Inequities Drive Antimicrobial Failure |
| title_full | Invisible Engines of Resistance: How Global Inequities Drive Antimicrobial Failure |
| title_fullStr | Invisible Engines of Resistance: How Global Inequities Drive Antimicrobial Failure |
| title_full_unstemmed | Invisible Engines of Resistance: How Global Inequities Drive Antimicrobial Failure |
| title_short | Invisible Engines of Resistance: How Global Inequities Drive Antimicrobial Failure |
| title_sort | invisible engines of resistance how global inequities drive antimicrobial failure |
| topic | antimicrobial resistance socioeconomic inequities antibiotics resistance genes global health |
| url | https://www.mdpi.com/2079-6382/14/7/659 |
| work_keys_str_mv | AT selimmehmeteke invisibleenginesofresistancehowglobalinequitiesdriveantimicrobialfailure AT arnoldcua invisibleenginesofresistancehowglobalinequitiesdriveantimicrobialfailure |