2-Hydroxyisobutyric acid targeted binding to MT-ND3 boosts mitochondrial respiratory chain homeostasis in hippocampus to rescue diabetic cognitive impairment

2-Hydroxyisobutyric acid targeted binding to MT-ND3 boosts mitochondrial respiratory chain homeostasis in hippocampus to rescue diabetic cognitive impairment

Background: The prevalence of diabetic cognitive impairment (DCI) is significant, some studies have shown that it is related to mitochondrial respiratory chain homeostasis, but the specific mechanism is not clear. 2-hydroxyisobutyric acid (2-HIBA) is a novel short-chain fatty acid with potential app...

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Bibliographic Details
Main Authors: Minzhen Xie, Siqi Gu, Yan Liu, Haolin Yang, Yuqi Wang, Wei Yin, Yang Hong, Wanying Lu, Chengbing He, Lin Li, Limin Zhao, Jianjia Zhang, Heng Liu, Tian Lan, Shuijie Li, Qi Wang
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Redox Biology
Subjects:
2-Hydroxyisobutyric acid
Short-chain fatty acids
Diabetic
Cognitive impairment
MT-ND3
Metabonomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724004245
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