Long-Term Human Immune Reconstitution, T-Cell Development, and Immune Reactivity in Mice Lacking the Murine Major Histocompatibility Complex: Validation with Cellular and Gene Expression Profiles

Long-Term Human Immune Reconstitution, T-Cell Development, and Immune Reactivity in Mice Lacking the Murine Major Histocompatibility Complex: Validation with Cellular and Gene Expression Profiles

Background: Humanized mice transplanted with CD34<sup>+</sup> hematopoietic cells (HPCs) are broadly used to study human immune responses and infections in vivo and for testing therapies pre-clinically. However, until now, it was not clear whether interactions between the mouse major his...

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Bibliographic Details
Main Authors: Milita Darguzyte, Philipp Antczak, Daniel Bachurski, Patrick Hoelker, Nima Abedpour, Rahil Gholamipoorfard, Hans A. Schlößer, Kerstin Wennhold, Martin Thelen, Maria A. Garcia-Marquez, Johannes Koenig, Andreas Schneider, Tobias Braun, Frank Klawonn, Michael Damrat, Masudur Rahman, Jan-Malte Kleid, Sebastian J. Theobald, Eugen Bauer, Constantin von Kaisenberg, Steven R. Talbot, Leonard D. Shultz, Brian Soper, Renata Stripecke
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Cells
Subjects:
stem cell transplantation
NSG
humanized mice
MHC
HLA
T-cell
Online Access:https://www.mdpi.com/2073-4409/13/20/1686
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