Bioengineering strategies for regeneration of skin integrity: A literature review
Objective: The skin is a complex organ that includes various stem cell populations. Current approaches for non-healing skin defects are sometimes inadequate and many attempts have been made to regenerate skin integrity. The aim of this review is to bridge the gap between basic research and clinical...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Regenerative Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320424002268 |
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| author | Makoto Shiraishi Yoshihiro Sowa Ataru Sunaga Kenta Yamamoto Mutsumi Okazaki |
| author_facet | Makoto Shiraishi Yoshihiro Sowa Ataru Sunaga Kenta Yamamoto Mutsumi Okazaki |
| author_sort | Makoto Shiraishi |
| collection | DOAJ |
| description | Objective: The skin is a complex organ that includes various stem cell populations. Current approaches for non-healing skin defects are sometimes inadequate and many attempts have been made to regenerate skin integrity. The aim of this review is to bridge the gap between basic research and clinical application of skin integrity regeneration. Methods: A literature search was carried out in PubMed using combinations of the keywords “skin integrity”, “tissue-engineered skin”, “bioengineered skin”, and “skin regeneration”. Articles published from 1968 to 2023 reporting evidence from in vivo and in vitro skin regeneration experiments were included. Results: These articles showed that stem cells can be differentiated into normal skin cells, including keratinocytes, and are a significant source of skin organoids, which are useful for investigating skin biology; and that emerging direct reprogramming methods have great potential to regenerate skin from the wounded skin surface. Conclusion: Recent advances in skin regeneration will facilitate further advancement of both basic and clinical research in skin biology. |
| format | Article |
| id | doaj-art-633b2038e7714c898aa26ac478fbbf5e |
| institution | DOAJ |
| issn | 2352-3204 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj-art-633b2038e7714c898aa26ac478fbbf5e2025-08-20T02:58:29ZengElsevierRegenerative Therapy2352-32042025-03-012815316010.1016/j.reth.2024.12.006Bioengineering strategies for regeneration of skin integrity: A literature reviewMakoto Shiraishi0Yoshihiro Sowa1Ataru Sunaga2Kenta Yamamoto3Mutsumi Okazaki4Department of Plastic and Reconstructive Surgery, The University of Tokyo Hospital, Tokyo, JapanDepartment of Plastic Surgery, Jichi Medical University, Japan; Corresponding author. Department of Plastic Surgery, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.Department of Plastic Surgery, Jichi Medical University, JapanDepartment of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Plastic and Reconstructive Surgery, The University of Tokyo Hospital, Tokyo, JapanObjective: The skin is a complex organ that includes various stem cell populations. Current approaches for non-healing skin defects are sometimes inadequate and many attempts have been made to regenerate skin integrity. The aim of this review is to bridge the gap between basic research and clinical application of skin integrity regeneration. Methods: A literature search was carried out in PubMed using combinations of the keywords “skin integrity”, “tissue-engineered skin”, “bioengineered skin”, and “skin regeneration”. Articles published from 1968 to 2023 reporting evidence from in vivo and in vitro skin regeneration experiments were included. Results: These articles showed that stem cells can be differentiated into normal skin cells, including keratinocytes, and are a significant source of skin organoids, which are useful for investigating skin biology; and that emerging direct reprogramming methods have great potential to regenerate skin from the wounded skin surface. Conclusion: Recent advances in skin regeneration will facilitate further advancement of both basic and clinical research in skin biology.http://www.sciencedirect.com/science/article/pii/S2352320424002268Skin integrityTissue-engineered skinBioengineered skinSkin regenerationRegenerative medicine |
| spellingShingle | Makoto Shiraishi Yoshihiro Sowa Ataru Sunaga Kenta Yamamoto Mutsumi Okazaki Bioengineering strategies for regeneration of skin integrity: A literature review Regenerative Therapy Skin integrity Tissue-engineered skin Bioengineered skin Skin regeneration Regenerative medicine |
| title | Bioengineering strategies for regeneration of skin integrity: A literature review |
| title_full | Bioengineering strategies for regeneration of skin integrity: A literature review |
| title_fullStr | Bioengineering strategies for regeneration of skin integrity: A literature review |
| title_full_unstemmed | Bioengineering strategies for regeneration of skin integrity: A literature review |
| title_short | Bioengineering strategies for regeneration of skin integrity: A literature review |
| title_sort | bioengineering strategies for regeneration of skin integrity a literature review |
| topic | Skin integrity Tissue-engineered skin Bioengineered skin Skin regeneration Regenerative medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2352320424002268 |
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