Aspartate Aminotransferase to Alanine Aminotransferase Ratio and Arterial Stiffness in Persian Cohort Study
Introduction Liver function tests such as AST/ALT ratio may play an important role in the progression of nonalcoholic fatty liver disease (NAFLD) and its related cardiovascular dysfunctions. The study aims to assess whether AST/ALT was associated with arterial stiffness in a large population-based c...
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Mashhad University of Medical Sciences
2023-04-01
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| Series: | Patient Safety and Quality Improvement Journal |
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| Online Access: | https://psj.mums.ac.ir/article_22628_0a9766b6362313af8cd634aef09c5432.pdf |
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| author | Sahar Sobhani Sara Raji Fatemeh Roudi Mohamad Amin Bakhshali Dina Javidjam Effat Saghi Zahra Ataee Saeed Eslami Hasan Abadi |
| author_facet | Sahar Sobhani Sara Raji Fatemeh Roudi Mohamad Amin Bakhshali Dina Javidjam Effat Saghi Zahra Ataee Saeed Eslami Hasan Abadi |
| author_sort | Sahar Sobhani |
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| description | Introduction Liver function tests such as AST/ALT ratio may play an important role in the progression of nonalcoholic fatty liver disease (NAFLD) and its related cardiovascular dysfunctions. The study aims to assess whether AST/ALT was associated with arterial stiffness in a large population-based cohort of apparently healthy Persian women and men.Material and Methods: To evaluate arterial stiffness non-invasively, Pulse Wave Velocity (PWV) and Augmentation Index (AI) were measured in 5031 healthy adults. Laboratory parameters, including AST and ALT, were measured after all subject's blood samples were collected. The one-way-ANOVA, the Kruskal-Wallis, and chi-square tests were used to compare the AST/ALT ratio among groups with baseline characteristics of participants following the calculation of AST: ALT through the division of AST levels by ALT levels. The univariate linear regression model was used to assess the association between mean pulse wave velocity (PWV) and AST/ALT ratio quartiles. Results: The results showed no statically significant difference in Age, HR, and MET among the different AST/ALT groups. Univariate analysis displayed that age, SBP, DBP, FBS, TG, MET, Fatty liver status, and hypertension status were positively correlated with Mean PWV. Evaluation of univariate linear regression models presented that AST/ALT has a significant correlation with Mean PWV (β = -0.139, 95% confidence interval (CI): -0.032 to -0.021, P-value < 0.001). We found that there was no linear relationship.Conclusions: According to the present study results, there was a significant negative correlation between AST/ALT with PWV. Moreover, a non-linear relationship between AST/ALT and PWV was observed as well. |
| format | Article |
| id | doaj-art-63342bd17c1246a2a5ea0f270dc42c62 |
| institution | DOAJ |
| issn | 2345-4482 2345-4490 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Mashhad University of Medical Sciences |
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| series | Patient Safety and Quality Improvement Journal |
| spelling | doaj-art-63342bd17c1246a2a5ea0f270dc42c622025-08-20T02:46:00ZengMashhad University of Medical SciencesPatient Safety and Quality Improvement Journal2345-44822345-44902023-04-0111211312010.22038/psj.2023.67592.137422628Aspartate Aminotransferase to Alanine Aminotransferase Ratio and Arterial Stiffness in Persian Cohort StudySahar Sobhani0Sara Raji1Fatemeh Roudi2Mohamad Amin Bakhshali3Dina Javidjam4Effat Saghi5Zahra Ataee6Saeed Eslami Hasan Abadi7Persian Cohort Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Persian Cohort Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranPostdoc Researcher, Department of Medical Informatics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranSchool of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranIntroduction Liver function tests such as AST/ALT ratio may play an important role in the progression of nonalcoholic fatty liver disease (NAFLD) and its related cardiovascular dysfunctions. The study aims to assess whether AST/ALT was associated with arterial stiffness in a large population-based cohort of apparently healthy Persian women and men.Material and Methods: To evaluate arterial stiffness non-invasively, Pulse Wave Velocity (PWV) and Augmentation Index (AI) were measured in 5031 healthy adults. Laboratory parameters, including AST and ALT, were measured after all subject's blood samples were collected. The one-way-ANOVA, the Kruskal-Wallis, and chi-square tests were used to compare the AST/ALT ratio among groups with baseline characteristics of participants following the calculation of AST: ALT through the division of AST levels by ALT levels. The univariate linear regression model was used to assess the association between mean pulse wave velocity (PWV) and AST/ALT ratio quartiles. Results: The results showed no statically significant difference in Age, HR, and MET among the different AST/ALT groups. Univariate analysis displayed that age, SBP, DBP, FBS, TG, MET, Fatty liver status, and hypertension status were positively correlated with Mean PWV. Evaluation of univariate linear regression models presented that AST/ALT has a significant correlation with Mean PWV (β = -0.139, 95% confidence interval (CI): -0.032 to -0.021, P-value < 0.001). We found that there was no linear relationship.Conclusions: According to the present study results, there was a significant negative correlation between AST/ALT with PWV. Moreover, a non-linear relationship between AST/ALT and PWV was observed as well.https://psj.mums.ac.ir/article_22628_0a9766b6362313af8cd634aef09c5432.pdfast/alt ratioarterial stiffnesscardiovascularpersian |
| spellingShingle | Sahar Sobhani Sara Raji Fatemeh Roudi Mohamad Amin Bakhshali Dina Javidjam Effat Saghi Zahra Ataee Saeed Eslami Hasan Abadi Aspartate Aminotransferase to Alanine Aminotransferase Ratio and Arterial Stiffness in Persian Cohort Study Patient Safety and Quality Improvement Journal ast/alt ratio arterial stiffness cardiovascular persian |
| title | Aspartate Aminotransferase to Alanine Aminotransferase Ratio and Arterial Stiffness in Persian Cohort Study |
| title_full | Aspartate Aminotransferase to Alanine Aminotransferase Ratio and Arterial Stiffness in Persian Cohort Study |
| title_fullStr | Aspartate Aminotransferase to Alanine Aminotransferase Ratio and Arterial Stiffness in Persian Cohort Study |
| title_full_unstemmed | Aspartate Aminotransferase to Alanine Aminotransferase Ratio and Arterial Stiffness in Persian Cohort Study |
| title_short | Aspartate Aminotransferase to Alanine Aminotransferase Ratio and Arterial Stiffness in Persian Cohort Study |
| title_sort | aspartate aminotransferase to alanine aminotransferase ratio and arterial stiffness in persian cohort study |
| topic | ast/alt ratio arterial stiffness cardiovascular persian |
| url | https://psj.mums.ac.ir/article_22628_0a9766b6362313af8cd634aef09c5432.pdf |
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