Tetranectin and Paraoxonase 1 in Patients with Varying Stages of Heart Failure: A Cross-Sectional Analysis
<b>Background:</b> Heart failure (HF) is a leading cause of mortality across the globe, prompting ongoing research into novel biomarkers for improved risk stratification and patient management. <b>Methods:</b> This cross-sectional study aimed to investigate the relationship b...
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MDPI AG
2025-04-01
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| author | Paula Alexandra Vulciu Luminita Pilat Maria-Daniela Mot Voicu Dascau Calin Daniel Popa Norberth-Istvan Varga Maria Puschita |
| author_facet | Paula Alexandra Vulciu Luminita Pilat Maria-Daniela Mot Voicu Dascau Calin Daniel Popa Norberth-Istvan Varga Maria Puschita |
| author_sort | Paula Alexandra Vulciu |
| collection | DOAJ |
| description | <b>Background:</b> Heart failure (HF) is a leading cause of mortality across the globe, prompting ongoing research into novel biomarkers for improved risk stratification and patient management. <b>Methods:</b> This cross-sectional study aimed to investigate the relationship between two promising biomarkers, tetranectin and paraoxonase 1, and the severity of heart failure in a cohort of 87 patients with cardiovascular risk factors. Participants were categorized into three groups based on their New York Heart Association (NYHA) classification: no HF (Control), NYHA class I (G1), and NYHA class II-IV (G2). <b>Results:</b> Our analysis revealed a stepwise decrease in both TETRA and PON1 levels with increasing HF severity, with the Control group exhibiting the highest levels and the G2 group the lowest. Interestingly, a significant positive correlation between TETRA and PON1 was observed only in the Control group, suggesting a potential interplay between these biomarkers in healthy individuals that may be disrupted with the onset of HF. Furthermore, both TETRA and PON1 were positively associated with left ventricular ejection fraction (LVEF) and negatively associated with diastolic dysfunction, indicating their potential involvement in both systolic and diastolic cardiac function. <b>Conclusions:</b> These findings suggest that TETRA and PON1 may serve as valuable biomarkers for assessing HF severity and prognosis. Further research is warranted to validate these findings in larger, prospective studies and to explore their clinical utility in guiding treatment decisions. |
| format | Article |
| id | doaj-art-632e49ea4daf454ba089a8c9deab9b77 |
| institution | OA Journals |
| issn | 2039-7283 |
| language | English |
| publishDate | 2025-04-01 |
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| series | Clinics and Practice |
| spelling | doaj-art-632e49ea4daf454ba089a8c9deab9b772025-08-20T01:56:16ZengMDPI AGClinics and Practice2039-72832025-04-011558610.3390/clinpract15050086Tetranectin and Paraoxonase 1 in Patients with Varying Stages of Heart Failure: A Cross-Sectional AnalysisPaula Alexandra Vulciu0Luminita Pilat1Maria-Daniela Mot2Voicu Dascau3Calin Daniel Popa4Norberth-Istvan Varga5Maria Puschita6Department of Biochemistry, “Vasile Goldis” Western University, B-dul Revolutiei Nr. 96, 310025 Arad, RomaniaDepartment of Biochemistry, “Vasile Goldis” Western University, B-dul Revolutiei Nr. 96, 310025 Arad, RomaniaDepartment of General Medicine, “Vasile Goldis” Western University, B-dul Revolutiei Nr. 96, 310025 Arad, RomaniaDepartment of Obstetrics and Gynecology, Medlife-Genesys Clinic, Dr. Cornel Radu Nr. 3, 310329 Arad, RomaniaSaint Luke of Crimeea Medical Center, B-dul Nicolae Titulescu Nr. 332, 310328 Arad, RomaniaDoctoral School, Department of General Medicine, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment of Internal Medicine, “Vasile Goldis” Western University, B-dul Revolutiei Nr. 96, 310025 Arad, Romania<b>Background:</b> Heart failure (HF) is a leading cause of mortality across the globe, prompting ongoing research into novel biomarkers for improved risk stratification and patient management. <b>Methods:</b> This cross-sectional study aimed to investigate the relationship between two promising biomarkers, tetranectin and paraoxonase 1, and the severity of heart failure in a cohort of 87 patients with cardiovascular risk factors. Participants were categorized into three groups based on their New York Heart Association (NYHA) classification: no HF (Control), NYHA class I (G1), and NYHA class II-IV (G2). <b>Results:</b> Our analysis revealed a stepwise decrease in both TETRA and PON1 levels with increasing HF severity, with the Control group exhibiting the highest levels and the G2 group the lowest. Interestingly, a significant positive correlation between TETRA and PON1 was observed only in the Control group, suggesting a potential interplay between these biomarkers in healthy individuals that may be disrupted with the onset of HF. Furthermore, both TETRA and PON1 were positively associated with left ventricular ejection fraction (LVEF) and negatively associated with diastolic dysfunction, indicating their potential involvement in both systolic and diastolic cardiac function. <b>Conclusions:</b> These findings suggest that TETRA and PON1 may serve as valuable biomarkers for assessing HF severity and prognosis. Further research is warranted to validate these findings in larger, prospective studies and to explore their clinical utility in guiding treatment decisions.https://www.mdpi.com/2039-7283/15/5/86heart failuretetranectinparaoxonase 1heart failure biomarkersheart failure severityechocardiography |
| spellingShingle | Paula Alexandra Vulciu Luminita Pilat Maria-Daniela Mot Voicu Dascau Calin Daniel Popa Norberth-Istvan Varga Maria Puschita Tetranectin and Paraoxonase 1 in Patients with Varying Stages of Heart Failure: A Cross-Sectional Analysis Clinics and Practice heart failure tetranectin paraoxonase 1 heart failure biomarkers heart failure severity echocardiography |
| title | Tetranectin and Paraoxonase 1 in Patients with Varying Stages of Heart Failure: A Cross-Sectional Analysis |
| title_full | Tetranectin and Paraoxonase 1 in Patients with Varying Stages of Heart Failure: A Cross-Sectional Analysis |
| title_fullStr | Tetranectin and Paraoxonase 1 in Patients with Varying Stages of Heart Failure: A Cross-Sectional Analysis |
| title_full_unstemmed | Tetranectin and Paraoxonase 1 in Patients with Varying Stages of Heart Failure: A Cross-Sectional Analysis |
| title_short | Tetranectin and Paraoxonase 1 in Patients with Varying Stages of Heart Failure: A Cross-Sectional Analysis |
| title_sort | tetranectin and paraoxonase 1 in patients with varying stages of heart failure a cross sectional analysis |
| topic | heart failure tetranectin paraoxonase 1 heart failure biomarkers heart failure severity echocardiography |
| url | https://www.mdpi.com/2039-7283/15/5/86 |
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