Genetic characterization and estimated 4CMenB vaccine strain coverage of 284 Neisseria meningitidis isolates causing invasive meningococcal disease in Argentina in 2010–2014
Meningococcal (Neisseria meningitidis) serogroup B (MenB) strain antigens are diverse and a limited number of strains can be evaluated using the human serum bactericidal antibody (hSBA) assay. The genetic Meningococcal Antigen Typing System (gMATS) was developed to predict the likelihood of coverage...
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2378537 |
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| author | Adriana Efron Alessandro Brozzi Alessia Biolchi Margherita Bodini Maria Giuliani Silvia Guidotti Federico Lorenzo María Alicia Moscoloni Alessandro Muzzi Florencia Nocita Mariagrazia Pizza Rino Rappuoli Sara Tomei Gabriela Vidal Carla Vizzotti Josefina Campos Cecilia Sorhouet Pereira |
| author_facet | Adriana Efron Alessandro Brozzi Alessia Biolchi Margherita Bodini Maria Giuliani Silvia Guidotti Federico Lorenzo María Alicia Moscoloni Alessandro Muzzi Florencia Nocita Mariagrazia Pizza Rino Rappuoli Sara Tomei Gabriela Vidal Carla Vizzotti Josefina Campos Cecilia Sorhouet Pereira |
| author_sort | Adriana Efron |
| collection | DOAJ |
| description | Meningococcal (Neisseria meningitidis) serogroup B (MenB) strain antigens are diverse and a limited number of strains can be evaluated using the human serum bactericidal antibody (hSBA) assay. The genetic Meningococcal Antigen Typing System (gMATS) was developed to predict the likelihood of coverage for large numbers of isolates by the 4CMenB vaccine, which includes antigens Neisseria adhesin A (NadA), Neisserial Heparin-Binding Antigen (NHBA), factor H-binding protein (fHbp), and Porin A (PorA). In this study, we characterized by whole-genome analyses 284 invasive MenB isolates collected from 2010 to 2014 by the Argentinian National Laboratories Network (52–61 isolates per year). Strain coverage was estimated by gMATS on all isolates and by hSBA assay on 74 randomly selected isolates, representative of the whole panel. The four most common clonal complexes (CCs), accounting for 81.3% of isolates, were CC-865 (75 isolates, 26.4%), CC-32 (59, 20.8%), CC-35 (59, 20.8%), and CC-41/44 (38, 13.4%). Vaccine antigen genotyping showed diversity. The most prevalent variants/peptides were fHbp variant 2, NHBA peptides 24, 21, and 2, and PorA variable region 2 profiles 16–36 and 14. The nadA gene was present in 66 (23.2%) isolates. Estimated strain coverage by hSBA assay showed 78.4% of isolates were killed by pooled adolescent sera, and 51.4% and 64.9% (based on two different thresholds) were killed by pooled infant sera. Estimated coverage by gMATS (61.3%; prediction interval: 55.5%, 66.7%) was consistent with the infant hSBA assay results. Continued genomic surveillance is needed to evaluate the persistence of major MenB CCs in Argentina. |
| format | Article |
| id | doaj-art-632b67600d7841ac9afc9f3eeb4db909 |
| institution | OA Journals |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2024-12-01 |
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| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-632b67600d7841ac9afc9f3eeb4db9092025-08-20T02:16:49ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2378537Genetic characterization and estimated 4CMenB vaccine strain coverage of 284 Neisseria meningitidis isolates causing invasive meningococcal disease in Argentina in 2010–2014Adriana Efron0Alessandro Brozzi1Alessia Biolchi2Margherita Bodini3Maria Giuliani4Silvia Guidotti5Federico Lorenzo6María Alicia Moscoloni7Alessandro Muzzi8Florencia Nocita9Mariagrazia Pizza10Rino Rappuoli11Sara Tomei12Gabriela Vidal13Carla Vizzotti14Josefina Campos15Cecilia Sorhouet Pereira16Instituto Nacional de Enfermedades Infecciosas-ANLIS “Dr. Carlos G. Malbrán”, Buenos Aires, ArgentinaGSK, Siena, ItalyGSK, Siena, ItalyGSK, Siena, ItalyGSK, Siena, ItalyGSK, Siena, ItalyInstituto Nacional de Enfermedades Infecciosas-ANLIS “Dr. Carlos G. Malbrán”, Buenos Aires, ArgentinaInstituto Nacional de Enfermedades Infecciosas-ANLIS “Dr. Carlos G. Malbrán”, Buenos Aires, ArgentinaGSK, Siena, ItalyGSK, Buenos Aires, ArgentinaGSK, Siena, ItalyGSK, Siena, ItalyGSK, Siena, ItalyGSK, Buenos Aires, ArgentinaNational Ministry of Health (2010-2015 and 2019–2023), Buenos Aires, ArgentinaInstituto Nacional de Enfermedades Infecciosas-ANLIS “Dr. Carlos G. Malbrán”, Buenos Aires, ArgentinaInstituto Nacional de Enfermedades Infecciosas-ANLIS “Dr. Carlos G. Malbrán”, Buenos Aires, ArgentinaMeningococcal (Neisseria meningitidis) serogroup B (MenB) strain antigens are diverse and a limited number of strains can be evaluated using the human serum bactericidal antibody (hSBA) assay. The genetic Meningococcal Antigen Typing System (gMATS) was developed to predict the likelihood of coverage for large numbers of isolates by the 4CMenB vaccine, which includes antigens Neisseria adhesin A (NadA), Neisserial Heparin-Binding Antigen (NHBA), factor H-binding protein (fHbp), and Porin A (PorA). In this study, we characterized by whole-genome analyses 284 invasive MenB isolates collected from 2010 to 2014 by the Argentinian National Laboratories Network (52–61 isolates per year). Strain coverage was estimated by gMATS on all isolates and by hSBA assay on 74 randomly selected isolates, representative of the whole panel. The four most common clonal complexes (CCs), accounting for 81.3% of isolates, were CC-865 (75 isolates, 26.4%), CC-32 (59, 20.8%), CC-35 (59, 20.8%), and CC-41/44 (38, 13.4%). Vaccine antigen genotyping showed diversity. The most prevalent variants/peptides were fHbp variant 2, NHBA peptides 24, 21, and 2, and PorA variable region 2 profiles 16–36 and 14. The nadA gene was present in 66 (23.2%) isolates. Estimated strain coverage by hSBA assay showed 78.4% of isolates were killed by pooled adolescent sera, and 51.4% and 64.9% (based on two different thresholds) were killed by pooled infant sera. Estimated coverage by gMATS (61.3%; prediction interval: 55.5%, 66.7%) was consistent with the infant hSBA assay results. Continued genomic surveillance is needed to evaluate the persistence of major MenB CCs in Argentina.https://www.tandfonline.com/doi/10.1080/21645515.2024.23785374CMenBArgentinagMATShuman serum bactericidal assaymeningococcal diseaseNeisseria meningitidis |
| spellingShingle | Adriana Efron Alessandro Brozzi Alessia Biolchi Margherita Bodini Maria Giuliani Silvia Guidotti Federico Lorenzo María Alicia Moscoloni Alessandro Muzzi Florencia Nocita Mariagrazia Pizza Rino Rappuoli Sara Tomei Gabriela Vidal Carla Vizzotti Josefina Campos Cecilia Sorhouet Pereira Genetic characterization and estimated 4CMenB vaccine strain coverage of 284 Neisseria meningitidis isolates causing invasive meningococcal disease in Argentina in 2010–2014 Human Vaccines & Immunotherapeutics 4CMenB Argentina gMATS human serum bactericidal assay meningococcal disease Neisseria meningitidis |
| title | Genetic characterization and estimated 4CMenB vaccine strain coverage of 284 Neisseria meningitidis isolates causing invasive meningococcal disease in Argentina in 2010–2014 |
| title_full | Genetic characterization and estimated 4CMenB vaccine strain coverage of 284 Neisseria meningitidis isolates causing invasive meningococcal disease in Argentina in 2010–2014 |
| title_fullStr | Genetic characterization and estimated 4CMenB vaccine strain coverage of 284 Neisseria meningitidis isolates causing invasive meningococcal disease in Argentina in 2010–2014 |
| title_full_unstemmed | Genetic characterization and estimated 4CMenB vaccine strain coverage of 284 Neisseria meningitidis isolates causing invasive meningococcal disease in Argentina in 2010–2014 |
| title_short | Genetic characterization and estimated 4CMenB vaccine strain coverage of 284 Neisseria meningitidis isolates causing invasive meningococcal disease in Argentina in 2010–2014 |
| title_sort | genetic characterization and estimated 4cmenb vaccine strain coverage of 284 neisseria meningitidis isolates causing invasive meningococcal disease in argentina in 2010 2014 |
| topic | 4CMenB Argentina gMATS human serum bactericidal assay meningococcal disease Neisseria meningitidis |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2378537 |
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