Exploring the association between caffeine intake and benign prostatic hyperplasia: results from the NHANES 2005–2008
BackgroundCoffee is a physiologically active food component prevalent throughout the world, but the association between caffeine intake and benign prostatic hyperplasia (BPH) has been limited in extensive epidemiological studies.MethodsWe conducted a cross-sectional study to evaluate the association...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1511607/full |
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| author | Fei Zhang Fei Zhang Fei Zhang Andong Zhang Andong Zhang Andong Zhang Junyue Tao Junyue Tao Junyue Tao Meng Zhang Meng Zhang Meng Zhang Chaozhao Liang Chaozhao Liang Chaozhao Liang |
| author_facet | Fei Zhang Fei Zhang Fei Zhang Andong Zhang Andong Zhang Andong Zhang Junyue Tao Junyue Tao Junyue Tao Meng Zhang Meng Zhang Meng Zhang Chaozhao Liang Chaozhao Liang Chaozhao Liang |
| author_sort | Fei Zhang |
| collection | DOAJ |
| description | BackgroundCoffee is a physiologically active food component prevalent throughout the world, but the association between caffeine intake and benign prostatic hyperplasia (BPH) has been limited in extensive epidemiological studies.MethodsWe conducted a cross-sectional study to evaluate the association between caffeine intake and BPH in adults in the United States using data from the National Health and Nutrition Examination Survey (NHANES) 2005–2008. Caffeine intake (mg/day) was evaluated based on a 24-h dietary recall. Multivariate logistic regression was used to analyze the independent relationship between caffeine intake and BPH, and the results are presented as odds ratio (OR) and 95% confidence interval (CI), subgroup analysis was also performed.ResultsA total of 2,374 participants were analyzed. After fully adjusting for potential confounders, logistic regression analysis revealed that higher caffeine intake was associated with a greater risk of BPH (ORT3vs1 = 1.52, 95% CI: 1.01–2.27; p = 0.04). In addition, this relationship was consistently observed across different subgroups, including individuals with lower education levels, a poverty income ratio (PIR) of 1.5 to 3.5, former smokers, married/living with partner individuals, those with uric acid levels of 5.5 to 6.5 mg/dL, those with hypertension, and those without cardiovascular disease (CVD).ConclusionThis study is the first to find a positive correlation between caffeine intake and BPH, but further research is needed to determine the exact causal relationship between these factors. |
| format | Article |
| id | doaj-art-632ae3cc734046bdbbf5737443be3610 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-632ae3cc734046bdbbf5737443be36102025-01-13T15:06:39ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011110.3389/fnut.2024.15116071511607Exploring the association between caffeine intake and benign prostatic hyperplasia: results from the NHANES 2005–2008Fei Zhang0Fei Zhang1Fei Zhang2Andong Zhang3Andong Zhang4Andong Zhang5Junyue Tao6Junyue Tao7Junyue Tao8Meng Zhang9Meng Zhang10Meng Zhang11Chaozhao Liang12Chaozhao Liang13Chaozhao Liang14Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaInstitute of Urology, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaInstitute of Urology, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaInstitute of Urology, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaInstitute of Urology, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaInstitute of Urology, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, ChinaBackgroundCoffee is a physiologically active food component prevalent throughout the world, but the association between caffeine intake and benign prostatic hyperplasia (BPH) has been limited in extensive epidemiological studies.MethodsWe conducted a cross-sectional study to evaluate the association between caffeine intake and BPH in adults in the United States using data from the National Health and Nutrition Examination Survey (NHANES) 2005–2008. Caffeine intake (mg/day) was evaluated based on a 24-h dietary recall. Multivariate logistic regression was used to analyze the independent relationship between caffeine intake and BPH, and the results are presented as odds ratio (OR) and 95% confidence interval (CI), subgroup analysis was also performed.ResultsA total of 2,374 participants were analyzed. After fully adjusting for potential confounders, logistic regression analysis revealed that higher caffeine intake was associated with a greater risk of BPH (ORT3vs1 = 1.52, 95% CI: 1.01–2.27; p = 0.04). In addition, this relationship was consistently observed across different subgroups, including individuals with lower education levels, a poverty income ratio (PIR) of 1.5 to 3.5, former smokers, married/living with partner individuals, those with uric acid levels of 5.5 to 6.5 mg/dL, those with hypertension, and those without cardiovascular disease (CVD).ConclusionThis study is the first to find a positive correlation between caffeine intake and BPH, but further research is needed to determine the exact causal relationship between these factors.https://www.frontiersin.org/articles/10.3389/fnut.2024.1511607/fullcaffeine intakecoffeebenign prostatic hyperplasiaNHANESmen’s health |
| spellingShingle | Fei Zhang Fei Zhang Fei Zhang Andong Zhang Andong Zhang Andong Zhang Junyue Tao Junyue Tao Junyue Tao Meng Zhang Meng Zhang Meng Zhang Chaozhao Liang Chaozhao Liang Chaozhao Liang Exploring the association between caffeine intake and benign prostatic hyperplasia: results from the NHANES 2005–2008 Frontiers in Nutrition caffeine intake coffee benign prostatic hyperplasia NHANES men’s health |
| title | Exploring the association between caffeine intake and benign prostatic hyperplasia: results from the NHANES 2005–2008 |
| title_full | Exploring the association between caffeine intake and benign prostatic hyperplasia: results from the NHANES 2005–2008 |
| title_fullStr | Exploring the association between caffeine intake and benign prostatic hyperplasia: results from the NHANES 2005–2008 |
| title_full_unstemmed | Exploring the association between caffeine intake and benign prostatic hyperplasia: results from the NHANES 2005–2008 |
| title_short | Exploring the association between caffeine intake and benign prostatic hyperplasia: results from the NHANES 2005–2008 |
| title_sort | exploring the association between caffeine intake and benign prostatic hyperplasia results from the nhanes 2005 2008 |
| topic | caffeine intake coffee benign prostatic hyperplasia NHANES men’s health |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1511607/full |
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