IL-23 blockade in a patient with psoriasis and reactivation history: Case report and review
Toxoplasma gondii infection can lead to severe disease in immunocompromised patients. Current systemic therapies in psoriasis rely on varying degrees of immunomodulation. Few studies have investigated the involvement of key cytokines targeted by these novel therapies (interleukins 23 and 17) in the...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-02-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X251320196 |
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| _version_ | 1850196675723788288 |
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| author | J. Dagher J. Ringuet |
| author_facet | J. Dagher J. Ringuet |
| author_sort | J. Dagher |
| collection | DOAJ |
| description | Toxoplasma gondii infection can lead to severe disease in immunocompromised patients. Current systemic therapies in psoriasis rely on varying degrees of immunomodulation. Few studies have investigated the involvement of key cytokines targeted by these novel therapies (interleukins 23 and 17) in the immune response against T. gondii . We describe a case of a patient with severe plaque psoriasis and a history of frequent ocular toxoplasmosis reactivations successfully treated using anti-IL-23 therapy without T. gondii reactivation. A brief scoping review of the literature is presented to address current data on toxoplasmosis and biologic therapy for psoriasis. |
| format | Article |
| id | doaj-art-6329c6b9a7264509a1a8e4bfd8a06d98 |
| institution | OA Journals |
| issn | 2050-313X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj-art-6329c6b9a7264509a1a8e4bfd8a06d982025-08-20T02:13:23ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2025-02-011310.1177/2050313X251320196IL-23 blockade in a patient with psoriasis and reactivation history: Case report and reviewJ. Dagher0J. Ringuet1Mailman School of Public Health, Columbia University, New York City, NY, USACentre de Recherche Dermatologique de Québec, Quebec City, QC, CanadaToxoplasma gondii infection can lead to severe disease in immunocompromised patients. Current systemic therapies in psoriasis rely on varying degrees of immunomodulation. Few studies have investigated the involvement of key cytokines targeted by these novel therapies (interleukins 23 and 17) in the immune response against T. gondii . We describe a case of a patient with severe plaque psoriasis and a history of frequent ocular toxoplasmosis reactivations successfully treated using anti-IL-23 therapy without T. gondii reactivation. A brief scoping review of the literature is presented to address current data on toxoplasmosis and biologic therapy for psoriasis.https://doi.org/10.1177/2050313X251320196 |
| spellingShingle | J. Dagher J. Ringuet IL-23 blockade in a patient with psoriasis and reactivation history: Case report and review SAGE Open Medical Case Reports |
| title | IL-23 blockade in a patient with psoriasis and reactivation history: Case report and review |
| title_full | IL-23 blockade in a patient with psoriasis and reactivation history: Case report and review |
| title_fullStr | IL-23 blockade in a patient with psoriasis and reactivation history: Case report and review |
| title_full_unstemmed | IL-23 blockade in a patient with psoriasis and reactivation history: Case report and review |
| title_short | IL-23 blockade in a patient with psoriasis and reactivation history: Case report and review |
| title_sort | il 23 blockade in a patient with psoriasis and reactivation history case report and review |
| url | https://doi.org/10.1177/2050313X251320196 |
| work_keys_str_mv | AT jdagher il23blockadeinapatientwithpsoriasisandreactivationhistorycasereportandreview AT jringuet il23blockadeinapatientwithpsoriasisandreactivationhistorycasereportandreview |