A Rare Case of Immunotactoid Glomerulopathy Associated with Hodgkin Lymphoma
Immunotactoid glomerulopathy (ITG) is characterized by Congo red-negative microtubular deposits, and it has been reported as a rare paraneoplastic syndrome due to hematologic malignancies, viral infections, or autoimmune diseases. In hematologic malignancies, multiple myeloma and other mature B-cell...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2021/5527966 |
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| author | Keiki Nagaharu Yuka Sugimoto Keiki Kawakami |
| author_facet | Keiki Nagaharu Yuka Sugimoto Keiki Kawakami |
| author_sort | Keiki Nagaharu |
| collection | DOAJ |
| description | Immunotactoid glomerulopathy (ITG) is characterized by Congo red-negative microtubular deposits, and it has been reported as a rare paraneoplastic syndrome due to hematologic malignancies, viral infections, or autoimmune diseases. In hematologic malignancies, multiple myeloma and other mature B-cell malignancies are the most common hematologic malignancies, and Hodgkin lymphoma (HL) is extremely rare. A 59-year-old woman was admitted to our hospital because of a pulmonary mass and proteinuria. Computed tomography-guided lung biopsy confirmed the presence of HL stage IIA. Immunofixation of peripheral blood was positive for immunoglobulin G (IgG) kappa. Renal biopsy showed mesangial proliferation with deposits in the subendothelial lesion and no invasion of the HL. These deposits were positive for IgG3, C3, and kappa light chain but negative for C1q and lambda light chain. Electron microscopy showed randomly aligned tubular structures with a diameter of approximately 50 nm. We diagnosed the patient with immunotactoid nephropathy and HL. After systemic chemotherapy, the patient achieved a complete response and loss of proteinuria. On the contrary, her serum monoclonal gammopathy was observed after chemotherapy. The existence of a monoclonal antibody itself might not be a sufficient factor for ITG in some cases, and an additive trigger is necessary for development. |
| format | Article |
| id | doaj-art-632849dc90484a50b35ff78f51b75a2f |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-632849dc90484a50b35ff78f51b75a2f2025-02-03T01:03:58ZengWileyCase Reports in Nephrology2090-66412090-665X2021-01-01202110.1155/2021/55279665527966A Rare Case of Immunotactoid Glomerulopathy Associated with Hodgkin LymphomaKeiki Nagaharu0Yuka Sugimoto1Keiki Kawakami2Department of Hematology and Oncology, Suzuka General Hospital, Yamanohana 1275-53, Suzuka 513-8630, Mie Prefecture, JapanDepartment of Hematology and Oncology, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu 514-8507, Mie Prefecture, JapanDepartment of Hematology and Oncology, Suzuka General Hospital, Yamanohana 1275-53, Suzuka 513-8630, Mie Prefecture, JapanImmunotactoid glomerulopathy (ITG) is characterized by Congo red-negative microtubular deposits, and it has been reported as a rare paraneoplastic syndrome due to hematologic malignancies, viral infections, or autoimmune diseases. In hematologic malignancies, multiple myeloma and other mature B-cell malignancies are the most common hematologic malignancies, and Hodgkin lymphoma (HL) is extremely rare. A 59-year-old woman was admitted to our hospital because of a pulmonary mass and proteinuria. Computed tomography-guided lung biopsy confirmed the presence of HL stage IIA. Immunofixation of peripheral blood was positive for immunoglobulin G (IgG) kappa. Renal biopsy showed mesangial proliferation with deposits in the subendothelial lesion and no invasion of the HL. These deposits were positive for IgG3, C3, and kappa light chain but negative for C1q and lambda light chain. Electron microscopy showed randomly aligned tubular structures with a diameter of approximately 50 nm. We diagnosed the patient with immunotactoid nephropathy and HL. After systemic chemotherapy, the patient achieved a complete response and loss of proteinuria. On the contrary, her serum monoclonal gammopathy was observed after chemotherapy. The existence of a monoclonal antibody itself might not be a sufficient factor for ITG in some cases, and an additive trigger is necessary for development.http://dx.doi.org/10.1155/2021/5527966 |
| spellingShingle | Keiki Nagaharu Yuka Sugimoto Keiki Kawakami A Rare Case of Immunotactoid Glomerulopathy Associated with Hodgkin Lymphoma Case Reports in Nephrology |
| title | A Rare Case of Immunotactoid Glomerulopathy Associated with Hodgkin Lymphoma |
| title_full | A Rare Case of Immunotactoid Glomerulopathy Associated with Hodgkin Lymphoma |
| title_fullStr | A Rare Case of Immunotactoid Glomerulopathy Associated with Hodgkin Lymphoma |
| title_full_unstemmed | A Rare Case of Immunotactoid Glomerulopathy Associated with Hodgkin Lymphoma |
| title_short | A Rare Case of Immunotactoid Glomerulopathy Associated with Hodgkin Lymphoma |
| title_sort | rare case of immunotactoid glomerulopathy associated with hodgkin lymphoma |
| url | http://dx.doi.org/10.1155/2021/5527966 |
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