The biological role and molecular mechanism of transfer RNA-derived small RNAs in tumor metastasis
Tumor metastasis is a significant contributor to increased cancer mortality. Transfer RNA-derived small RNAs (tsRNAs), a class of endogenous non-coding RNA molecules, play crucial functional roles in various physiological processes, including the regulation of transcription and reverse transcription...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-04-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1560943/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850216020635025408 |
|---|---|
| author | Haotian Dong Haotian Dong Chengyuan Ye Xiaohan Ye Jianing Yan Guoliang Ye Yongfu Shao Yongfu Shao |
| author_facet | Haotian Dong Haotian Dong Chengyuan Ye Xiaohan Ye Jianing Yan Guoliang Ye Yongfu Shao Yongfu Shao |
| author_sort | Haotian Dong |
| collection | DOAJ |
| description | Tumor metastasis is a significant contributor to increased cancer mortality. Transfer RNA-derived small RNAs (tsRNAs), a class of endogenous non-coding RNA molecules, play crucial functional roles in various physiological processes, including the regulation of transcription and reverse transcription, the modulation of translation processes, the modification of epigenetic inheritance, the regulation of the cell cycle, etc. Dysregulated tsRNAs are closely related to the occurrence and progression of human malignancies. Accumulating evidence indicates that the abnormal expression of tsRNAs is associated with tumor metastasis through a variety of mechanisms. Hence, we summarize the fundamental structure and biological functions of tsRNAs, with a focus on how tsRNAs influence the tumor metastasis process through downstream targets or the regulation of interactions between upstream and downstream molecules, thereby providing a novel perspective for targeted therapy for tumor metastasis. |
| format | Article |
| id | doaj-art-6321ab50b13d4d2a8446d4bddac610b8 |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-6321ab50b13d4d2a8446d4bddac610b82025-08-20T02:08:26ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-04-011510.3389/fonc.2025.15609431560943The biological role and molecular mechanism of transfer RNA-derived small RNAs in tumor metastasisHaotian Dong0Haotian Dong1Chengyuan Ye2Xiaohan Ye3Jianing Yan4Guoliang Ye5Yongfu Shao6Yongfu Shao7Department of Gastroenterology, the First Affiliated Hospital of Ningbo University, Ningbo, ChinaHealth Science Center, Ningbo University, Ningbo, ChinaHealth Science Center, Ningbo University, Ningbo, ChinaHealth Science Center, Ningbo University, Ningbo, ChinaDepartment of Gastroenterology, the First Affiliated Hospital of Ningbo University, Ningbo, ChinaDepartment of Gastroenterology, the First Affiliated Hospital of Ningbo University, Ningbo, ChinaDepartment of Gastroenterology, the First Affiliated Hospital of Ningbo University, Ningbo, ChinaHealth Science Center, Ningbo University, Ningbo, ChinaTumor metastasis is a significant contributor to increased cancer mortality. Transfer RNA-derived small RNAs (tsRNAs), a class of endogenous non-coding RNA molecules, play crucial functional roles in various physiological processes, including the regulation of transcription and reverse transcription, the modulation of translation processes, the modification of epigenetic inheritance, the regulation of the cell cycle, etc. Dysregulated tsRNAs are closely related to the occurrence and progression of human malignancies. Accumulating evidence indicates that the abnormal expression of tsRNAs is associated with tumor metastasis through a variety of mechanisms. Hence, we summarize the fundamental structure and biological functions of tsRNAs, with a focus on how tsRNAs influence the tumor metastasis process through downstream targets or the regulation of interactions between upstream and downstream molecules, thereby providing a novel perspective for targeted therapy for tumor metastasis.https://www.frontiersin.org/articles/10.3389/fonc.2025.1560943/fulltsRNAtumor metastasissignaling pathwayepithelial-mesenchymal transitiontumor microenvironment |
| spellingShingle | Haotian Dong Haotian Dong Chengyuan Ye Xiaohan Ye Jianing Yan Guoliang Ye Yongfu Shao Yongfu Shao The biological role and molecular mechanism of transfer RNA-derived small RNAs in tumor metastasis Frontiers in Oncology tsRNA tumor metastasis signaling pathway epithelial-mesenchymal transition tumor microenvironment |
| title | The biological role and molecular mechanism of transfer RNA-derived small RNAs in tumor metastasis |
| title_full | The biological role and molecular mechanism of transfer RNA-derived small RNAs in tumor metastasis |
| title_fullStr | The biological role and molecular mechanism of transfer RNA-derived small RNAs in tumor metastasis |
| title_full_unstemmed | The biological role and molecular mechanism of transfer RNA-derived small RNAs in tumor metastasis |
| title_short | The biological role and molecular mechanism of transfer RNA-derived small RNAs in tumor metastasis |
| title_sort | biological role and molecular mechanism of transfer rna derived small rnas in tumor metastasis |
| topic | tsRNA tumor metastasis signaling pathway epithelial-mesenchymal transition tumor microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1560943/full |
| work_keys_str_mv | AT haotiandong thebiologicalroleandmolecularmechanismoftransferrnaderivedsmallrnasintumormetastasis AT haotiandong thebiologicalroleandmolecularmechanismoftransferrnaderivedsmallrnasintumormetastasis AT chengyuanye thebiologicalroleandmolecularmechanismoftransferrnaderivedsmallrnasintumormetastasis AT xiaohanye thebiologicalroleandmolecularmechanismoftransferrnaderivedsmallrnasintumormetastasis AT jianingyan thebiologicalroleandmolecularmechanismoftransferrnaderivedsmallrnasintumormetastasis AT guoliangye thebiologicalroleandmolecularmechanismoftransferrnaderivedsmallrnasintumormetastasis AT yongfushao thebiologicalroleandmolecularmechanismoftransferrnaderivedsmallrnasintumormetastasis AT yongfushao thebiologicalroleandmolecularmechanismoftransferrnaderivedsmallrnasintumormetastasis AT haotiandong biologicalroleandmolecularmechanismoftransferrnaderivedsmallrnasintumormetastasis AT haotiandong biologicalroleandmolecularmechanismoftransferrnaderivedsmallrnasintumormetastasis AT chengyuanye biologicalroleandmolecularmechanismoftransferrnaderivedsmallrnasintumormetastasis AT xiaohanye biologicalroleandmolecularmechanismoftransferrnaderivedsmallrnasintumormetastasis AT jianingyan biologicalroleandmolecularmechanismoftransferrnaderivedsmallrnasintumormetastasis AT guoliangye biologicalroleandmolecularmechanismoftransferrnaderivedsmallrnasintumormetastasis AT yongfushao biologicalroleandmolecularmechanismoftransferrnaderivedsmallrnasintumormetastasis AT yongfushao biologicalroleandmolecularmechanismoftransferrnaderivedsmallrnasintumormetastasis |