History of pre-eclampsia does not appear to be a risk factor for vascular phenotype in women with systemic sclerosis
Background Vascular phenotype is associated with a poor prognosis in systemic sclerosis (SSc). The identification of its risk factors could facilitate its early detection.Objectives To explore risk factors for a vascular phenotype of SSc, among them a history of pre-eclampsia.Methods This observatio...
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BMJ Publishing Group
2024-02-01
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| Online Access: | https://rmdopen.bmj.com/content/10/1/e003626.full |
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| author | Arsène Mekinian Eric Hachulla Alain Lescoat Elisabeth Pasquier Christian Agard Sabine Berthier Perrine Smets Grégory Pugnet Emmanuel Chatelus Marie-Elise Truchetet Viviane Queyrel Nathalie Tieulie Bénédicte Rouvière Claire de Moreuil Emilie Brenaut Valérie Devauchelle-Pensec Olivier Lidove Jérémy Keraen Benjamin Subran Nicolas Belhomme Elizabeth Diot Mathieu Delplanque Sandy Lucier Emmanuelle Courtois-Communier |
| author_facet | Arsène Mekinian Eric Hachulla Alain Lescoat Elisabeth Pasquier Christian Agard Sabine Berthier Perrine Smets Grégory Pugnet Emmanuel Chatelus Marie-Elise Truchetet Viviane Queyrel Nathalie Tieulie Bénédicte Rouvière Claire de Moreuil Emilie Brenaut Valérie Devauchelle-Pensec Olivier Lidove Jérémy Keraen Benjamin Subran Nicolas Belhomme Elizabeth Diot Mathieu Delplanque Sandy Lucier Emmanuelle Courtois-Communier |
| author_sort | Arsène Mekinian |
| collection | DOAJ |
| description | Background Vascular phenotype is associated with a poor prognosis in systemic sclerosis (SSc). The identification of its risk factors could facilitate its early detection.Objectives To explore risk factors for a vascular phenotype of SSc, among them a history of pre-eclampsia.Methods This observational multicentre case–control study enrolled adult women fulfilling European Alliance of Associations for Rheumatology 2013 diagnosis criteria for SSc and having a pregnancy history≥6 months before SSc diagnosis in 14 French hospital-based recruiting centres from July 2020 to July 2022. Cases had specific vascular complications of SSc defined as history of digital ischaemic ulcers, pulmonary arterial hypertension, specific cardiac involvement or renal crisis. Women with SSc were included during their annual follow-up visit and filled in a self-administered questionnaire about pregnancy. A case report form was completed by their physician, reporting data on medical history, physical examination, clinical investigations and current medication. The main outcome was the presence/absence of a personal history of pre-eclampsia before SSc diagnosis, according to the validated pre-eclampsia questionnaire.Results 378 women were included: 129 cases with a vascular phenotype and 249 matched controls. A history of pre-eclampsia was reported in 5 (3.9%) cases and 12 (4.8%) controls and was not associated with a vascular phenotype (OR=0.96, 95% CI 0.28 to 3.34, p=0.9). Besides, Rodnan skin score and disease duration≥5 years were risk factors for vascular phenotype.Conclusions In women with SSc and a pregnancy history≥6 months before SSc, a history of pre-eclampsia is not associated with a vascular phenotype. |
| format | Article |
| id | doaj-art-6319c42ac36f4eab9db833bfc1630052 |
| institution | Kabale University |
| issn | 2056-5933 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj-art-6319c42ac36f4eab9db833bfc16300522025-08-20T03:52:19ZengBMJ Publishing GroupRMD Open2056-59332024-02-0110110.1136/rmdopen-2023-003626History of pre-eclampsia does not appear to be a risk factor for vascular phenotype in women with systemic sclerosisArsène Mekinian0Eric Hachulla1Alain Lescoat2Elisabeth Pasquier3Christian Agard4Sabine Berthier5Perrine Smets6Grégory Pugnet7Emmanuel Chatelus8Marie-Elise Truchetet9Viviane Queyrel10Nathalie Tieulie11Bénédicte Rouvière12Claire de Moreuil13Emilie Brenaut14Valérie Devauchelle-Pensec15Olivier Lidove16Jérémy Keraen17Benjamin Subran18Nicolas Belhomme19Elizabeth Diot20Mathieu Delplanque21Sandy Lucier22Emmanuelle Courtois-Communier23Internal Medicine, DHUi2B, Saint Antoine Hospital, AP HP, Université Pierre et Marie Curie, Paris, FranceUniv. Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille, FranceDepartment of Internal Medicine and Clinical Immunology, CHU de Rennes, Rennes, FranceInternal Medicine, Vascular Medicine and Pneumology Department, Brest University Hospital, Brest, FranceInternal Medicine, Nantes University Hospital, Nantes, FranceService de médecine interne et immunologie clinique, Université Dijon, Hôpital Dijon, Dijon, FranceCentre Hospitalier Universitaire Gabriel-Montpied, Service de Médecine Interne, Centre de Référence pour les Maladies auto immunes et auto inflammatoires Systémiques Rares d`Auvergne, 63000 Clermont-Ferrand, France, Clermont-Ferrand, FranceInternal Medicine Department, Toulouse III University-Paul Sabatier Faculty of Health, Toulouse, FranceRheumatology, Hopitaux universitaires de Strasbourg, Strasbourg, FranceRheumatology, Bordeaux University Hospital, Bordeaux, FranceInternal Medicine, Nice Cote d`Azur University, Nice, FranceRheumatology, Pasteur Hospital, Nice University Hospital, Nice Sophia Antipolis University, Nice, FranceU1227, LBAI, Univ Brest, Inserm, and CHU Brest, Brest, France, Brest, FranceMédecine interne et pneumologie, CHU de Brest, Brest, FranceDermatology, Brest University Hospital, Brest, FranceEA 22-16,INSERM ESPRI, ERI29, Brest, FranceDepartment of Internal Medicine, Groupe hospitalier Diaconesses Croix Saint-Simon, Paris, Île-de-France, FranceInternal Medicine, Hospital Centre Cornouaille, Quimper, FranceDepartment of Internal Medicine, La Croix Saint-Simon Hospital, Paris, FranceDepartment of Internal Medicine and Clinical Immunology, CHU de Rennes, Rennes, FranceInternal Medicine, Regional University Hospital Centre Tours, Tours, FranceInternal Medicine, Vascular Medicine and Pneumology Department, Brest University Hospital, Brest, FranceCIC 1412, INSERM, Brest University Hospital, Brest, FranceCIC 1412, INSERM, Brest University Hospital, Brest, FranceBackground Vascular phenotype is associated with a poor prognosis in systemic sclerosis (SSc). The identification of its risk factors could facilitate its early detection.Objectives To explore risk factors for a vascular phenotype of SSc, among them a history of pre-eclampsia.Methods This observational multicentre case–control study enrolled adult women fulfilling European Alliance of Associations for Rheumatology 2013 diagnosis criteria for SSc and having a pregnancy history≥6 months before SSc diagnosis in 14 French hospital-based recruiting centres from July 2020 to July 2022. Cases had specific vascular complications of SSc defined as history of digital ischaemic ulcers, pulmonary arterial hypertension, specific cardiac involvement or renal crisis. Women with SSc were included during their annual follow-up visit and filled in a self-administered questionnaire about pregnancy. A case report form was completed by their physician, reporting data on medical history, physical examination, clinical investigations and current medication. The main outcome was the presence/absence of a personal history of pre-eclampsia before SSc diagnosis, according to the validated pre-eclampsia questionnaire.Results 378 women were included: 129 cases with a vascular phenotype and 249 matched controls. A history of pre-eclampsia was reported in 5 (3.9%) cases and 12 (4.8%) controls and was not associated with a vascular phenotype (OR=0.96, 95% CI 0.28 to 3.34, p=0.9). Besides, Rodnan skin score and disease duration≥5 years were risk factors for vascular phenotype.Conclusions In women with SSc and a pregnancy history≥6 months before SSc, a history of pre-eclampsia is not associated with a vascular phenotype.https://rmdopen.bmj.com/content/10/1/e003626.full |
| spellingShingle | Arsène Mekinian Eric Hachulla Alain Lescoat Elisabeth Pasquier Christian Agard Sabine Berthier Perrine Smets Grégory Pugnet Emmanuel Chatelus Marie-Elise Truchetet Viviane Queyrel Nathalie Tieulie Bénédicte Rouvière Claire de Moreuil Emilie Brenaut Valérie Devauchelle-Pensec Olivier Lidove Jérémy Keraen Benjamin Subran Nicolas Belhomme Elizabeth Diot Mathieu Delplanque Sandy Lucier Emmanuelle Courtois-Communier History of pre-eclampsia does not appear to be a risk factor for vascular phenotype in women with systemic sclerosis RMD Open |
| title | History of pre-eclampsia does not appear to be a risk factor for vascular phenotype in women with systemic sclerosis |
| title_full | History of pre-eclampsia does not appear to be a risk factor for vascular phenotype in women with systemic sclerosis |
| title_fullStr | History of pre-eclampsia does not appear to be a risk factor for vascular phenotype in women with systemic sclerosis |
| title_full_unstemmed | History of pre-eclampsia does not appear to be a risk factor for vascular phenotype in women with systemic sclerosis |
| title_short | History of pre-eclampsia does not appear to be a risk factor for vascular phenotype in women with systemic sclerosis |
| title_sort | history of pre eclampsia does not appear to be a risk factor for vascular phenotype in women with systemic sclerosis |
| url | https://rmdopen.bmj.com/content/10/1/e003626.full |
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