Sr-MOF-based hydrogel promotes diabetic tissue regeneration through simultaneous antimicrobial and antiinflammatory properties
Severe tissue dysfunction in diabetic patients has been a challenging clinical problem. Both bacterial infections and chronic inflammation contribute to diabetic microenvironmental disorders and poor tissue regeneration. In this paper, a composite hydrogel (Gelma@Sr-ZIF-8) was prepared by incorporat...
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Elsevier
2025-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425004764 |
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| author | Siming Zhang Gaoran Ge Wenhao Li Jiale Dong Xianli Hu Yi Qin Peng Zhang Jiaxiang Bai Weiwei Zhang Zheng Su Dechun Geng Chen Zhu |
| author_facet | Siming Zhang Gaoran Ge Wenhao Li Jiale Dong Xianli Hu Yi Qin Peng Zhang Jiaxiang Bai Weiwei Zhang Zheng Su Dechun Geng Chen Zhu |
| author_sort | Siming Zhang |
| collection | DOAJ |
| description | Severe tissue dysfunction in diabetic patients has been a challenging clinical problem. Both bacterial infections and chronic inflammation contribute to diabetic microenvironmental disorders and poor tissue regeneration. In this paper, a composite hydrogel (Gelma@Sr-ZIF-8) was prepared by incorporating a strontium (Sr)-doped metal-organic framework (Sr-ZIF-8) into Gelatin methacryloyl (Gelma) hydrogel, which could reverse diabetic microenvironmental disorders and promote tissue regeneration in diabetic wounds. The zinc ions released from this hydrogel directly killed invading planktonic bacteria and inhibited biofilm formation. Moreover, zinc ions can disrupt biofilm structure, penetrate bacteria and remove biofilm. In addition, strontium and zinc ions reversed the pro-inflammatory immune microenvironment by modulating redox balance, restored phagocytosis by macrophages, and killed bacteria released from mature biofilms. In addition, strontium ions promote the proliferation and differentiation of osteoblasts, inhibit the activity of osteoclasts, and promote the regeneration of blood vessels at the site of bone defects, ultimately promoting the regeneration of diabetic tissue. The synergistic effect of zinc and strontium ions gives Gelma@Sr-ZIF-8 excellent full-stage antibacterial and immunomodulatory properties. In vitro and in vivo studies have shown that Gelma@Sr-ZIF-8 can remodel the disturbed diabetic microenvironment, ultimately improving the efficacy of antimicrobial therapy and promoting diabetic tissue regeneration. |
| format | Article |
| id | doaj-art-631343187edc42d2af86fcccf4db4c5c |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-631343187edc42d2af86fcccf4db4c5c2025-08-20T02:17:27ZengElsevierMaterials Today Bio2590-00642025-06-013210190610.1016/j.mtbio.2025.101906Sr-MOF-based hydrogel promotes diabetic tissue regeneration through simultaneous antimicrobial and antiinflammatory propertiesSiming Zhang0Gaoran Ge1Wenhao Li2Jiale Dong3Xianli Hu4Yi Qin5Peng Zhang6Jiaxiang Bai7Weiwei Zhang8Zheng Su9Dechun Geng10Chen Zhu11Department of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, China; Department of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, ChinaDepartment of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, ChinaDepartment of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, ChinaDepartment of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, ChinaDepartment of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, ChinaDepartment of Geriatrics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230022, China; Corresponding authors.Department of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China; Corresponding author. Department of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230022, China.Department of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, China; Corresponding authors. Department of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, China.Department of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China; Corresponding author. Department of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230022, China.Severe tissue dysfunction in diabetic patients has been a challenging clinical problem. Both bacterial infections and chronic inflammation contribute to diabetic microenvironmental disorders and poor tissue regeneration. In this paper, a composite hydrogel (Gelma@Sr-ZIF-8) was prepared by incorporating a strontium (Sr)-doped metal-organic framework (Sr-ZIF-8) into Gelatin methacryloyl (Gelma) hydrogel, which could reverse diabetic microenvironmental disorders and promote tissue regeneration in diabetic wounds. The zinc ions released from this hydrogel directly killed invading planktonic bacteria and inhibited biofilm formation. Moreover, zinc ions can disrupt biofilm structure, penetrate bacteria and remove biofilm. In addition, strontium and zinc ions reversed the pro-inflammatory immune microenvironment by modulating redox balance, restored phagocytosis by macrophages, and killed bacteria released from mature biofilms. In addition, strontium ions promote the proliferation and differentiation of osteoblasts, inhibit the activity of osteoclasts, and promote the regeneration of blood vessels at the site of bone defects, ultimately promoting the regeneration of diabetic tissue. The synergistic effect of zinc and strontium ions gives Gelma@Sr-ZIF-8 excellent full-stage antibacterial and immunomodulatory properties. In vitro and in vivo studies have shown that Gelma@Sr-ZIF-8 can remodel the disturbed diabetic microenvironment, ultimately improving the efficacy of antimicrobial therapy and promoting diabetic tissue regeneration.http://www.sciencedirect.com/science/article/pii/S2590006425004764DiabetesTissue regenerationReactive oxygen speciesFull-stage antibacterial |
| spellingShingle | Siming Zhang Gaoran Ge Wenhao Li Jiale Dong Xianli Hu Yi Qin Peng Zhang Jiaxiang Bai Weiwei Zhang Zheng Su Dechun Geng Chen Zhu Sr-MOF-based hydrogel promotes diabetic tissue regeneration through simultaneous antimicrobial and antiinflammatory properties Materials Today Bio Diabetes Tissue regeneration Reactive oxygen species Full-stage antibacterial |
| title | Sr-MOF-based hydrogel promotes diabetic tissue regeneration through simultaneous antimicrobial and antiinflammatory properties |
| title_full | Sr-MOF-based hydrogel promotes diabetic tissue regeneration through simultaneous antimicrobial and antiinflammatory properties |
| title_fullStr | Sr-MOF-based hydrogel promotes diabetic tissue regeneration through simultaneous antimicrobial and antiinflammatory properties |
| title_full_unstemmed | Sr-MOF-based hydrogel promotes diabetic tissue regeneration through simultaneous antimicrobial and antiinflammatory properties |
| title_short | Sr-MOF-based hydrogel promotes diabetic tissue regeneration through simultaneous antimicrobial and antiinflammatory properties |
| title_sort | sr mof based hydrogel promotes diabetic tissue regeneration through simultaneous antimicrobial and antiinflammatory properties |
| topic | Diabetes Tissue regeneration Reactive oxygen species Full-stage antibacterial |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425004764 |
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