DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies.
<h4>Background</h4>Polycystic ovarian syndrome is a heterogenous endocrine disorder characterized by irregular menstrual cycles, hirsuitism and polycystic ovaries. It is further complicated by metabolic syndrome, infertility and psychological stress. Although the etiopathogenesis is uncl...
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Public Library of Science (PLoS)
2021-01-01
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| author | Jiby Jolly Benjamin MaheshKumar K Teena Koshy Maruthy K N Padmavathi R |
| author_facet | Jiby Jolly Benjamin MaheshKumar K Teena Koshy Maruthy K N Padmavathi R |
| author_sort | Jiby Jolly Benjamin |
| collection | DOAJ |
| description | <h4>Background</h4>Polycystic ovarian syndrome is a heterogenous endocrine disorder characterized by irregular menstrual cycles, hirsuitism and polycystic ovaries. It is further complicated by metabolic syndrome, infertility and psychological stress. Although the etiopathogenesis is unclear, many studies have pointed out the role of stress in this syndrome. DHEA, being a stress marker is being used by scientists to compare the stress levels between polycystic ovarian cases and healthy controls. However, the results obtained from previous studies are equivocal.<h4>Objective</h4>To perform meta-analysis and find the association between stress and the syndrome.<h4>Data sources</h4>Relevant data till January 2021 were retrieved from PubMed, Scopus, Embase and Web of Science using MeSH terms.<h4>Study selection</h4>Case-control studies having PCOS subjects as cases and healthy women as controls were selected provided; their basal DHEA levels were mentioned in the published articles.<h4>Data extraction</h4>Two authors independently extracted the articles and qualified the final studies.<h4>Data synthesi</h4>Pooled meta-analysis was done using random effect model and showed level of DHEA statistically significant in PCOS compared to healthy controls (SMD = 1.15, 95% CI = 0.59-1.71).Heterogeneity was statistically significant as well (I2 = 95%).<h4>Conclusion</h4>Thismeta-analysis on DHEA and PCOS has helped in generating evidence regarding the involvement of stress in the pathogenesis of PCOS. |
| format | Article |
| id | doaj-art-6311af1a09f74194a8e03aa02c8df444 |
| institution | DOAJ |
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| language | English |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-6311af1a09f74194a8e03aa02c8df4442025-08-20T03:16:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011612e026155210.1371/journal.pone.0261552DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies.Jiby Jolly BenjaminMaheshKumar KTeena KoshyMaruthy K NPadmavathi R<h4>Background</h4>Polycystic ovarian syndrome is a heterogenous endocrine disorder characterized by irregular menstrual cycles, hirsuitism and polycystic ovaries. It is further complicated by metabolic syndrome, infertility and psychological stress. Although the etiopathogenesis is unclear, many studies have pointed out the role of stress in this syndrome. DHEA, being a stress marker is being used by scientists to compare the stress levels between polycystic ovarian cases and healthy controls. However, the results obtained from previous studies are equivocal.<h4>Objective</h4>To perform meta-analysis and find the association between stress and the syndrome.<h4>Data sources</h4>Relevant data till January 2021 were retrieved from PubMed, Scopus, Embase and Web of Science using MeSH terms.<h4>Study selection</h4>Case-control studies having PCOS subjects as cases and healthy women as controls were selected provided; their basal DHEA levels were mentioned in the published articles.<h4>Data extraction</h4>Two authors independently extracted the articles and qualified the final studies.<h4>Data synthesi</h4>Pooled meta-analysis was done using random effect model and showed level of DHEA statistically significant in PCOS compared to healthy controls (SMD = 1.15, 95% CI = 0.59-1.71).Heterogeneity was statistically significant as well (I2 = 95%).<h4>Conclusion</h4>Thismeta-analysis on DHEA and PCOS has helped in generating evidence regarding the involvement of stress in the pathogenesis of PCOS.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0261552&type=printable |
| spellingShingle | Jiby Jolly Benjamin MaheshKumar K Teena Koshy Maruthy K N Padmavathi R DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies. PLoS ONE |
| title | DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies. |
| title_full | DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies. |
| title_fullStr | DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies. |
| title_full_unstemmed | DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies. |
| title_short | DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies. |
| title_sort | dhea and polycystic ovarian syndrome meta analysis of case control studies |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0261552&type=printable |
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