In vitro and in vivo characterization of oridonin analogs as anti-inflammatory agents that regulate the NF-κB and NLRP3 inflammasome axis

In vitro and in vivo characterization of oridonin analogs as anti-inflammatory agents that regulate the NF-κB and NLRP3 inflammasome axis

IntroductionA series of oridonin hybrids were synthesized and evaluated for anti-inflammatory potential, focusing on their ability to inhibit NO production in RAW264.7 cells and their therapeutic prospects for NLRP3-driven disorders.MethodsAnti-inflammatory activity was assessed by measuring NO inhi...

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Bibliographic Details
Main Authors: Huiping Ou, Zhanpan Wu, Jinhua Ning, Qiufeng Huang, Wancun Wang, Guochun Yang, Yingxun Zhou, Anguo Hou, Peng Li, Lingyun Chen, Wen Bin Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
oridonin analogs
anti-inflammation
NLRP3 inflammasome
NF-κB signaling pathway
acute lung injury
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1512740/full
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