Cholangiocyte organoids for disease, cancer, and regenerative medicine
The biliary tract is a ductal network comprising the intrahepatic (IHBDs) and extrahepatic bile duct (EHBDs). Biliary duct disorders include cholangitis, neoplasms, and injury. However, the underlying mechanisms are not fully understood. With advancements in 3D culture technology, cholangiocyte orga...
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Elsevier
2025-03-01
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| Series: | European Journal of Cell Biology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S017193352400089X |
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| author | Munemasa Nagao Akihisa Fukuda Hirotaka Kashima Sho Matsuyama Kei Iimori Shinnosuke Nakayama Kenta Mizukoshi Munenori Kawai Go Yamakawa Mayuki Omatsu Mio Namikawa Tomonori Masuda Yukiko Hiramatsu Yu Muta Takahisa Maruno Yuki Nakanishi Tatsuaki Tsuruyama Hiroshi Seno |
| author_facet | Munemasa Nagao Akihisa Fukuda Hirotaka Kashima Sho Matsuyama Kei Iimori Shinnosuke Nakayama Kenta Mizukoshi Munenori Kawai Go Yamakawa Mayuki Omatsu Mio Namikawa Tomonori Masuda Yukiko Hiramatsu Yu Muta Takahisa Maruno Yuki Nakanishi Tatsuaki Tsuruyama Hiroshi Seno |
| author_sort | Munemasa Nagao |
| collection | DOAJ |
| description | The biliary tract is a ductal network comprising the intrahepatic (IHBDs) and extrahepatic bile duct (EHBDs). Biliary duct disorders include cholangitis, neoplasms, and injury. However, the underlying mechanisms are not fully understood. With advancements in 3D culture technology, cholangiocyte organoids (COs) derived from primary tissues or induced pluripotent stem cells (iPSCs) can accurately replicate the structural and functional properties of biliary tissues. These organoids have become powerful tools for studying the pathogenesis of biliary diseases, such as cystic fibrosis and primary sclerosing cholangitis, and for developing new therapeutic strategies for cholangiocarcinoma. Additionally, COs have the potential to repair bile duct injuries and facilitate transplantation therapies. This review also discusses the use of organoids in genetically engineered mouse models to provide mechanistic insights into tumorigenesis and cancer progression. Continued innovation and standardization of organoid technology are crucial for advancing precision medicine for biliary diseases and cancer. |
| format | Article |
| id | doaj-art-630d0d9852334301ae3518510e863aa9 |
| institution | Kabale University |
| issn | 0171-9335 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Cell Biology |
| spelling | doaj-art-630d0d9852334301ae3518510e863aa92025-01-23T05:26:15ZengElsevierEuropean Journal of Cell Biology0171-93352025-03-011041151472Cholangiocyte organoids for disease, cancer, and regenerative medicineMunemasa Nagao0Akihisa Fukuda1Hirotaka Kashima2Sho Matsuyama3Kei Iimori4Shinnosuke Nakayama5Kenta Mizukoshi6Munenori Kawai7Go Yamakawa8Mayuki Omatsu9Mio Namikawa10Tomonori Masuda11Yukiko Hiramatsu12Yu Muta13Takahisa Maruno14Yuki Nakanishi15Tatsuaki Tsuruyama16Hiroshi Seno17Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, JapanDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan; Corresponding author.Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan; Department of Gastroenterology and Hepatology, The Japan Baptist Hospital, 47 Yamanomoto-cho, Kitashirakawa, Sakyo-ku, Kyoto 606-8273, JapanDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Discovery Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, JapanDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanThe biliary tract is a ductal network comprising the intrahepatic (IHBDs) and extrahepatic bile duct (EHBDs). Biliary duct disorders include cholangitis, neoplasms, and injury. However, the underlying mechanisms are not fully understood. With advancements in 3D culture technology, cholangiocyte organoids (COs) derived from primary tissues or induced pluripotent stem cells (iPSCs) can accurately replicate the structural and functional properties of biliary tissues. These organoids have become powerful tools for studying the pathogenesis of biliary diseases, such as cystic fibrosis and primary sclerosing cholangitis, and for developing new therapeutic strategies for cholangiocarcinoma. Additionally, COs have the potential to repair bile duct injuries and facilitate transplantation therapies. This review also discusses the use of organoids in genetically engineered mouse models to provide mechanistic insights into tumorigenesis and cancer progression. Continued innovation and standardization of organoid technology are crucial for advancing precision medicine for biliary diseases and cancer.http://www.sciencedirect.com/science/article/pii/S017193352400089XCholangiocyte organoidCholangiocarcinomaBiliary cancerOrganoid |
| spellingShingle | Munemasa Nagao Akihisa Fukuda Hirotaka Kashima Sho Matsuyama Kei Iimori Shinnosuke Nakayama Kenta Mizukoshi Munenori Kawai Go Yamakawa Mayuki Omatsu Mio Namikawa Tomonori Masuda Yukiko Hiramatsu Yu Muta Takahisa Maruno Yuki Nakanishi Tatsuaki Tsuruyama Hiroshi Seno Cholangiocyte organoids for disease, cancer, and regenerative medicine European Journal of Cell Biology Cholangiocyte organoid Cholangiocarcinoma Biliary cancer Organoid |
| title | Cholangiocyte organoids for disease, cancer, and regenerative medicine |
| title_full | Cholangiocyte organoids for disease, cancer, and regenerative medicine |
| title_fullStr | Cholangiocyte organoids for disease, cancer, and regenerative medicine |
| title_full_unstemmed | Cholangiocyte organoids for disease, cancer, and regenerative medicine |
| title_short | Cholangiocyte organoids for disease, cancer, and regenerative medicine |
| title_sort | cholangiocyte organoids for disease cancer and regenerative medicine |
| topic | Cholangiocyte organoid Cholangiocarcinoma Biliary cancer Organoid |
| url | http://www.sciencedirect.com/science/article/pii/S017193352400089X |
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