Regulatory T Cells in Allogeneic Stem Cell Transplantation
Growing evidence suggests that cellular adoptive immunotherapy is becoming an attractive though challenging approach in regulating tumor immunity and alloresponses in clinical transplantation. Naturally arising CD4+CD25+Foxp3+ regulatory T cells (Treg) have emerged as a key component in this regard....
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/608951 |
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| _version_ | 1832565168135995392 |
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| author | Maria Michael Avichai Shimoni Arnon Nagler |
| author_facet | Maria Michael Avichai Shimoni Arnon Nagler |
| author_sort | Maria Michael |
| collection | DOAJ |
| description | Growing evidence suggests that cellular adoptive immunotherapy is becoming an attractive though challenging approach in regulating tumor immunity and alloresponses in clinical transplantation. Naturally arising CD4+CD25+Foxp3+ regulatory T cells (Treg) have emerged as a key component in this regard. Over the last decade, a large body of evidence from preclinical models has demonstrated their crucial role in auto- and tumor immunity and has opened the door to their “first-in-man” clinical application. Initial studies in clinical allogeneic stem cell transplantation are very encouraging and may pave the way for other applications. Further improvements in Treg ex vivo or in vivo expansion technologies will simplify their global clinical application. In this review, we discuss the current knowledge of Treg biology and their potential for cell-based immunotherapy in allogeneic stem cell transplantation. |
| format | Article |
| id | doaj-art-63098e73542140009d1785618f933e5b |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-63098e73542140009d1785618f933e5b2025-02-03T01:08:59ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/608951608951Regulatory T Cells in Allogeneic Stem Cell TransplantationMaria Michael0Avichai Shimoni1Arnon Nagler2Hematology Division & Bone Marrow Transplantation, Chaim Sheba Medical Center, Sackler Medical School, Tel Aviv University, Tel Aviv 52621, IsraelHematology Division & Bone Marrow Transplantation, Chaim Sheba Medical Center, Sackler Medical School, Tel Aviv University, Tel Aviv 52621, IsraelHematology Division & Bone Marrow Transplantation, Chaim Sheba Medical Center, Sackler Medical School, Tel Aviv University, Tel Aviv 52621, IsraelGrowing evidence suggests that cellular adoptive immunotherapy is becoming an attractive though challenging approach in regulating tumor immunity and alloresponses in clinical transplantation. Naturally arising CD4+CD25+Foxp3+ regulatory T cells (Treg) have emerged as a key component in this regard. Over the last decade, a large body of evidence from preclinical models has demonstrated their crucial role in auto- and tumor immunity and has opened the door to their “first-in-man” clinical application. Initial studies in clinical allogeneic stem cell transplantation are very encouraging and may pave the way for other applications. Further improvements in Treg ex vivo or in vivo expansion technologies will simplify their global clinical application. In this review, we discuss the current knowledge of Treg biology and their potential for cell-based immunotherapy in allogeneic stem cell transplantation.http://dx.doi.org/10.1155/2013/608951 |
| spellingShingle | Maria Michael Avichai Shimoni Arnon Nagler Regulatory T Cells in Allogeneic Stem Cell Transplantation Clinical and Developmental Immunology |
| title | Regulatory T Cells in Allogeneic Stem Cell Transplantation |
| title_full | Regulatory T Cells in Allogeneic Stem Cell Transplantation |
| title_fullStr | Regulatory T Cells in Allogeneic Stem Cell Transplantation |
| title_full_unstemmed | Regulatory T Cells in Allogeneic Stem Cell Transplantation |
| title_short | Regulatory T Cells in Allogeneic Stem Cell Transplantation |
| title_sort | regulatory t cells in allogeneic stem cell transplantation |
| url | http://dx.doi.org/10.1155/2013/608951 |
| work_keys_str_mv | AT mariamichael regulatorytcellsinallogeneicstemcelltransplantation AT avichaishimoni regulatorytcellsinallogeneicstemcelltransplantation AT arnonnagler regulatorytcellsinallogeneicstemcelltransplantation |