Genetic Dissection of Learning and Memory in Mice
In this minireview, we discuss different strategies to dissect genetically the keystones of learning and memory. First, we broadly sketch the neurogenetic analysis of complex traits in mice. We then discuss two general strategies to find genes affecting learning and memory: candidate gene studies an...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2004-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2004.217 |
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| _version_ | 1849696287785484288 |
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| author | Yann S. Mineur Wim E. Crusio Frans Sluyter |
| author_facet | Yann S. Mineur Wim E. Crusio Frans Sluyter |
| author_sort | Yann S. Mineur |
| collection | DOAJ |
| description | In this minireview, we discuss different strategies to dissect genetically the keystones of learning and memory. First, we broadly sketch the neurogenetic analysis of complex traits in mice. We then discuss two general strategies to find genes affecting learning and memory: candidate gene studies and whole genome searches. Next, we briefly review more recently developed techniques, such as microarrays and RNA interference. In addition, we focus on gene-environment interactions and endophenotypes. All sections are illustrated with examples from the learning and memory field, including a table summarizing the latest information about genes that have been shown to have effects on learning and memory. |
| format | Article |
| id | doaj-art-63020a351c634f27acec8f66928b00fe |
| institution | DOAJ |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-63020a351c634f27acec8f66928b00fe2025-08-20T03:19:31ZengWileyNeural Plasticity2090-59041687-54432004-01-01113-421724010.1155/NP.2004.217Genetic Dissection of Learning and Memory in MiceYann S. Mineur0Wim E. Crusio1Frans Sluyter2Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester 01604, MA, USABrudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester 01604, MA, USASGDP Research Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UKIn this minireview, we discuss different strategies to dissect genetically the keystones of learning and memory. First, we broadly sketch the neurogenetic analysis of complex traits in mice. We then discuss two general strategies to find genes affecting learning and memory: candidate gene studies and whole genome searches. Next, we briefly review more recently developed techniques, such as microarrays and RNA interference. In addition, we focus on gene-environment interactions and endophenotypes. All sections are illustrated with examples from the learning and memory field, including a table summarizing the latest information about genes that have been shown to have effects on learning and memory.http://dx.doi.org/10.1155/NP.2004.217 |
| spellingShingle | Yann S. Mineur Wim E. Crusio Frans Sluyter Genetic Dissection of Learning and Memory in Mice Neural Plasticity |
| title | Genetic Dissection of Learning and Memory in Mice |
| title_full | Genetic Dissection of Learning and Memory in Mice |
| title_fullStr | Genetic Dissection of Learning and Memory in Mice |
| title_full_unstemmed | Genetic Dissection of Learning and Memory in Mice |
| title_short | Genetic Dissection of Learning and Memory in Mice |
| title_sort | genetic dissection of learning and memory in mice |
| url | http://dx.doi.org/10.1155/NP.2004.217 |
| work_keys_str_mv | AT yannsmineur geneticdissectionoflearningandmemoryinmice AT wimecrusio geneticdissectionoflearningandmemoryinmice AT franssluyter geneticdissectionoflearningandmemoryinmice |