Study of vascular endothelial dysfunction in children with beta-thalassemia major before and after quercetin therapy

Study of vascular endothelial dysfunction in children with beta-thalassemia major before and after quercetin therapy

Abstract Background Beta-thalassemia stands as an autosomal recessive disorder that occurs as a result of a defect in the beta-globin chain synthesis of hemoglobin. Oxidative stress has a crucial role in the β-thalassemia pathophysiology. It occurs due to erythroid expansion along with ineffective e...

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Bibliographic Details
Main Authors: Fatma Al Zahraa Sherai, Maaly Mabrouk, Ibrahim Badraia, Adel Hagag, Eman Elaskary
Format: Article
Language:English
Published: SpringerOpen 2025-02-01
Series:Egyptian Pediatric Association Gazette
Subjects:
Thalassemia
Iron overload
Oxidative stress
Quercetin
ROS
Thrombomodulin
Online Access:https://doi.org/10.1186/s43054-025-00347-w
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