Low-dose intranasal deferoxamine modulates memory, neuroinflammation, and the neuronal transcriptome in the streptozotocin rodent model of Alzheimer’s disease

Low-dose intranasal deferoxamine modulates memory, neuroinflammation, and the neuronal transcriptome in the streptozotocin rodent model of Alzheimer’s disease

IntroductionIntranasal (IN) deferoxamine (DFO) has emerged over the past decade as a promising therapeutic in preclinical experiments across neurodegenerative and neurovascular diseases. As an antioxidant iron chelator, its mechanisms are multimodal, involving the binding of brain iron and the conse...

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Bibliographic Details
Main Authors: Jared M. Fine, Jacob Kosyakovsky, Tate T. Bowe, Katherine A. Faltesek, Benjamin M. Stroebel, Juan E. Abrahante, Michael R. Kelly, Elizabeth A. Thompson, Claire M. Westby, Kiley M. Robertson, William H. Frey, Leah R. Hanson
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Neuroscience
Subjects:
intranasal
deferoxamine
streptozotocin
Alzheimer’s disease
neuroinflammation
transcriptome
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1528374/full
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