Direct reprogramming of mouse fibroblasts into self-renewable alveolar epithelial-like cells

Direct reprogramming of mouse fibroblasts into self-renewable alveolar epithelial-like cells

Abstract Direct reprogramming is a breakthrough technology that can alter the fate of cells without the passage of stem cells. However, direct reprogramming of somatic cells into pulmonary alveolar epithelial cells has not yet been achieved. Here, we report the direct reprogramming of mouse tail tip...

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Main Authors: Atsuho Morita, Makoto Ishii, Takanori Asakura, Masaya Yotsukura, Ahmed E. Hegab, Tatsuya Kusumoto, Ho Namkoong, Takunori Ogawa, Yuhki Nakatake, Mayumi Oda, Fumitake Saito, Hirofumi Kamata, Junko Hamamoto, Satoshi Okamori, Toshiki Ebisudani, Hiroyuki Yasuda, Shinya Sugimoto, Yuta Kuze, Masahide Seki, Yutaka Suzuki, Naoki Hasegawa, Hisao Asamura, Hideo Watanabe, Minoru Ko, Toshiro Sato, Masaki Ieda, Koichi Fukunaga
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-025-00411-4
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