Mechanism of arsenic-induced liver injury in rats revealed by metabolomics and ionomics based approach
Abstracts: Arsenic (As) is an environmental toxicant and human carcinogen, long-term exposure to As can lead to varying degrees of liver injury. In this study, the liver injury model of As poisoned Sprague-Dawley (SD) rats was established, and the potential mechanism was investigated by metabonomics...
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Elsevier
2025-03-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325003744 |
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| author | Guanwei Ma Xi Yan Chao Wang Xiaoqian Ran Zhiyuan Liang Xiaolu Chen Ting Hu Xiaoxiao Tang Hongbin Zhuang Yuhan Huang Peng Luo Liming Shen |
| author_facet | Guanwei Ma Xi Yan Chao Wang Xiaoqian Ran Zhiyuan Liang Xiaolu Chen Ting Hu Xiaoxiao Tang Hongbin Zhuang Yuhan Huang Peng Luo Liming Shen |
| author_sort | Guanwei Ma |
| collection | DOAJ |
| description | Abstracts: Arsenic (As) is an environmental toxicant and human carcinogen, long-term exposure to As can lead to varying degrees of liver injury. In this study, the liver injury model of As poisoned Sprague-Dawley (SD) rats was established, and the potential mechanism was investigated by metabonomics and ionomics. A total of 164 differential expressed metabolites (DEMs) were identified between the As poisoned group and the control group, which mainly involved in nicotinate and nicotinamide metabolism, steroid hormone biosynthesis, taurine and hypotaurine metabolism, and porphyrin metabolism. The levels of 10 ions were significantly increased in As poisoned group, including As, bismuth (Bi), cadmium (Cd), mercury (Hg), manganese (Mn), rubidium (Rb), antimony (Sb), strontium (Sr), uranium(U), and zinc (Zn), in contrast, the levels of lead (Pb) and thallium (TI) were significantly decreased. Spearman correlation analysis showed that As, Cd, Hg and Pb were negatively correlated with androstenedione, protoporphyrinogen IX and estriol, whereas As and Mn was positively correlated with progesterone (PROG), Cd was positively correlated with NAD+ and 3-Sulfino-L-alanine. There are sex differences in changes in metabolites and ions levels. Male and female rats shared 60 DEMs and 2 pathways (steroid hormone biosynthesis and porphyrin metabolism pathway). The levels of As, Cd, Hg, and Sr were significantly changed in both male and female rats. In both female and male rats, As was positively correlated with PROG, and Cd was positively correlated with coproporphyrin III. The results of this study provide new insights to elucidate the mechanism of As-induced liver injury in rats. |
| format | Article |
| id | doaj-art-62e4cd2a216b44f2ace96983a23c4439 |
| institution | OA Journals |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-62e4cd2a216b44f2ace96983a23c44392025-08-20T01:49:28ZengElsevierEcotoxicology and Environmental Safety0147-65132025-03-0129311803810.1016/j.ecoenv.2025.118038Mechanism of arsenic-induced liver injury in rats revealed by metabolomics and ionomics based approachGuanwei Ma0Xi Yan1Chao Wang2Xiaoqian Ran3Zhiyuan Liang4Xiaolu Chen5Ting Hu6Xiaoxiao Tang7Hongbin Zhuang8Yuhan Huang9Peng Luo10Liming Shen11School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 561113, PR ChinaSchool of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 561113, PR ChinaChemical Analysis & Physical Testing Institute, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, PR ChinaSchool of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 561113, PR ChinaCollege of Life Science and Oceanography, Shenzhen University, Shenzhen 518060, PR ChinaSchool of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 561113, PR ChinaSchool of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 561113, PR ChinaCollege of Life Science and Oceanography, Shenzhen University, Shenzhen 518060, PR ChinaCollege of Life Science and Oceanography, Shenzhen University, Shenzhen 518060, PR ChinaCollege of Life Science and Oceanography, Shenzhen University, Shenzhen 518060, PR ChinaSchool of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 561113, PR China; Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry, Guizhou Medical University, Guiyang 561113, PR China; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine; Corresponding authors at: School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 561113, PR China.School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 561113, PR China; College of Life Science and Oceanography, Shenzhen University, Shenzhen 518060, PR China; Corresponding authors at: School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 561113, PR China.Abstracts: Arsenic (As) is an environmental toxicant and human carcinogen, long-term exposure to As can lead to varying degrees of liver injury. In this study, the liver injury model of As poisoned Sprague-Dawley (SD) rats was established, and the potential mechanism was investigated by metabonomics and ionomics. A total of 164 differential expressed metabolites (DEMs) were identified between the As poisoned group and the control group, which mainly involved in nicotinate and nicotinamide metabolism, steroid hormone biosynthesis, taurine and hypotaurine metabolism, and porphyrin metabolism. The levels of 10 ions were significantly increased in As poisoned group, including As, bismuth (Bi), cadmium (Cd), mercury (Hg), manganese (Mn), rubidium (Rb), antimony (Sb), strontium (Sr), uranium(U), and zinc (Zn), in contrast, the levels of lead (Pb) and thallium (TI) were significantly decreased. Spearman correlation analysis showed that As, Cd, Hg and Pb were negatively correlated with androstenedione, protoporphyrinogen IX and estriol, whereas As and Mn was positively correlated with progesterone (PROG), Cd was positively correlated with NAD+ and 3-Sulfino-L-alanine. There are sex differences in changes in metabolites and ions levels. Male and female rats shared 60 DEMs and 2 pathways (steroid hormone biosynthesis and porphyrin metabolism pathway). The levels of As, Cd, Hg, and Sr were significantly changed in both male and female rats. In both female and male rats, As was positively correlated with PROG, and Cd was positively correlated with coproporphyrin III. The results of this study provide new insights to elucidate the mechanism of As-induced liver injury in rats.http://www.sciencedirect.com/science/article/pii/S0147651325003744Correlation analysisElements imbalanceLiver injuryMetabolomicsSodium arsenite |
| spellingShingle | Guanwei Ma Xi Yan Chao Wang Xiaoqian Ran Zhiyuan Liang Xiaolu Chen Ting Hu Xiaoxiao Tang Hongbin Zhuang Yuhan Huang Peng Luo Liming Shen Mechanism of arsenic-induced liver injury in rats revealed by metabolomics and ionomics based approach Ecotoxicology and Environmental Safety Correlation analysis Elements imbalance Liver injury Metabolomics Sodium arsenite |
| title | Mechanism of arsenic-induced liver injury in rats revealed by metabolomics and ionomics based approach |
| title_full | Mechanism of arsenic-induced liver injury in rats revealed by metabolomics and ionomics based approach |
| title_fullStr | Mechanism of arsenic-induced liver injury in rats revealed by metabolomics and ionomics based approach |
| title_full_unstemmed | Mechanism of arsenic-induced liver injury in rats revealed by metabolomics and ionomics based approach |
| title_short | Mechanism of arsenic-induced liver injury in rats revealed by metabolomics and ionomics based approach |
| title_sort | mechanism of arsenic induced liver injury in rats revealed by metabolomics and ionomics based approach |
| topic | Correlation analysis Elements imbalance Liver injury Metabolomics Sodium arsenite |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325003744 |
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