Statins Diversity Revealed by the Deep-Sea-Derived Fungus <i>Penicillium viridicatum</i>
Seven new (<b>1</b>–<b>7</b>) and six known (<b>8</b>–<b>13</b>) statin derivatives were obtained from the deep-sea-derived fungus <i>Penicillium viridicatum</i> MCCC 3A00265. The structures assigned to the new compounds were based on a com...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-02-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/23/2/87 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850080197342134272 |
|---|---|
| author | Meng Zhang Rong Chao Jia-Jian Wang Zi-Han Xu Ji-Hong Zhang Da-Li Meng Tai-Zong Wu Xian-Wen Yang |
| author_facet | Meng Zhang Rong Chao Jia-Jian Wang Zi-Han Xu Ji-Hong Zhang Da-Li Meng Tai-Zong Wu Xian-Wen Yang |
| author_sort | Meng Zhang |
| collection | DOAJ |
| description | Seven new (<b>1</b>–<b>7</b>) and six known (<b>8</b>–<b>13</b>) statin derivatives were obtained from the deep-sea-derived fungus <i>Penicillium viridicatum</i> MCCC 3A00265. The structures assigned to the new compounds were based on a comprehensive analysis of the spectroscopic data, with absolute configurations established by Mosher analysis and biogenetic consideration. Most of the new compounds (<b>1</b>–<b>5</b> and <b>7</b>) share an octohydronaphthalene backbone, except that viridecalin F (<b>6</b>) possesses an uncommon naphthalene core. Viridecalins C (<b>3</b>) and F (<b>6</b>) and the two known compounds <b>9</b> and <b>11</b> exhibit considerable ability in reactivating mutant p53 protein at 10 μM, while viridecalin C showcases the most potent reactivation activity, indicating the potential of application in cancer therapy. |
| format | Article |
| id | doaj-art-62e0b8d561e642f893bb4876faa9215c |
| institution | DOAJ |
| issn | 1660-3397 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-62e0b8d561e642f893bb4876faa9215c2025-08-20T02:45:00ZengMDPI AGMarine Drugs1660-33972025-02-012328710.3390/md23020087Statins Diversity Revealed by the Deep-Sea-Derived Fungus <i>Penicillium viridicatum</i>Meng Zhang0Rong Chao1Jia-Jian Wang2Zi-Han Xu3Ji-Hong Zhang4Da-Li Meng5Tai-Zong Wu6Xian-Wen Yang7Hainan Academy of Medical Sciences, Hainan Medical University, 3 Xueyuan Road, Haikou 571199, ChinaKey Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Sources, 184 Daxue Road, Xiamen 361005, ChinaLaboratory of Molecular Pharmacology, Medical School, Kunming University of Science and Technology, Kunming 650500, ChinaHainan Academy of Medical Sciences, Hainan Medical University, 3 Xueyuan Road, Haikou 571199, ChinaLaboratory of Molecular Pharmacology, Medical School, Kunming University of Science and Technology, Kunming 650500, ChinaSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, ChinaKey Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Sources, 184 Daxue Road, Xiamen 361005, ChinaHainan Academy of Medical Sciences, Hainan Medical University, 3 Xueyuan Road, Haikou 571199, ChinaSeven new (<b>1</b>–<b>7</b>) and six known (<b>8</b>–<b>13</b>) statin derivatives were obtained from the deep-sea-derived fungus <i>Penicillium viridicatum</i> MCCC 3A00265. The structures assigned to the new compounds were based on a comprehensive analysis of the spectroscopic data, with absolute configurations established by Mosher analysis and biogenetic consideration. Most of the new compounds (<b>1</b>–<b>5</b> and <b>7</b>) share an octohydronaphthalene backbone, except that viridecalin F (<b>6</b>) possesses an uncommon naphthalene core. Viridecalins C (<b>3</b>) and F (<b>6</b>) and the two known compounds <b>9</b> and <b>11</b> exhibit considerable ability in reactivating mutant p53 protein at 10 μM, while viridecalin C showcases the most potent reactivation activity, indicating the potential of application in cancer therapy.https://www.mdpi.com/1660-3397/23/2/87deep-sea-derived fungusstatins<i>Penicillium viridicatum</i>mutant p53cancer |
| spellingShingle | Meng Zhang Rong Chao Jia-Jian Wang Zi-Han Xu Ji-Hong Zhang Da-Li Meng Tai-Zong Wu Xian-Wen Yang Statins Diversity Revealed by the Deep-Sea-Derived Fungus <i>Penicillium viridicatum</i> Marine Drugs deep-sea-derived fungus statins <i>Penicillium viridicatum</i> mutant p53 cancer |
| title | Statins Diversity Revealed by the Deep-Sea-Derived Fungus <i>Penicillium viridicatum</i> |
| title_full | Statins Diversity Revealed by the Deep-Sea-Derived Fungus <i>Penicillium viridicatum</i> |
| title_fullStr | Statins Diversity Revealed by the Deep-Sea-Derived Fungus <i>Penicillium viridicatum</i> |
| title_full_unstemmed | Statins Diversity Revealed by the Deep-Sea-Derived Fungus <i>Penicillium viridicatum</i> |
| title_short | Statins Diversity Revealed by the Deep-Sea-Derived Fungus <i>Penicillium viridicatum</i> |
| title_sort | statins diversity revealed by the deep sea derived fungus i penicillium viridicatum i |
| topic | deep-sea-derived fungus statins <i>Penicillium viridicatum</i> mutant p53 cancer |
| url | https://www.mdpi.com/1660-3397/23/2/87 |
| work_keys_str_mv | AT mengzhang statinsdiversityrevealedbythedeepseaderivedfungusipenicilliumviridicatumi AT rongchao statinsdiversityrevealedbythedeepseaderivedfungusipenicilliumviridicatumi AT jiajianwang statinsdiversityrevealedbythedeepseaderivedfungusipenicilliumviridicatumi AT zihanxu statinsdiversityrevealedbythedeepseaderivedfungusipenicilliumviridicatumi AT jihongzhang statinsdiversityrevealedbythedeepseaderivedfungusipenicilliumviridicatumi AT dalimeng statinsdiversityrevealedbythedeepseaderivedfungusipenicilliumviridicatumi AT taizongwu statinsdiversityrevealedbythedeepseaderivedfungusipenicilliumviridicatumi AT xianwenyang statinsdiversityrevealedbythedeepseaderivedfungusipenicilliumviridicatumi |