Statins Diversity Revealed by the Deep-Sea-Derived Fungus <i>Penicillium viridicatum</i>
Seven new (<b>1</b>–<b>7</b>) and six known (<b>8</b>–<b>13</b>) statin derivatives were obtained from the deep-sea-derived fungus <i>Penicillium viridicatum</i> MCCC 3A00265. The structures assigned to the new compounds were based on a com...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-02-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/23/2/87 |
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| Summary: | Seven new (<b>1</b>–<b>7</b>) and six known (<b>8</b>–<b>13</b>) statin derivatives were obtained from the deep-sea-derived fungus <i>Penicillium viridicatum</i> MCCC 3A00265. The structures assigned to the new compounds were based on a comprehensive analysis of the spectroscopic data, with absolute configurations established by Mosher analysis and biogenetic consideration. Most of the new compounds (<b>1</b>–<b>5</b> and <b>7</b>) share an octohydronaphthalene backbone, except that viridecalin F (<b>6</b>) possesses an uncommon naphthalene core. Viridecalins C (<b>3</b>) and F (<b>6</b>) and the two known compounds <b>9</b> and <b>11</b> exhibit considerable ability in reactivating mutant p53 protein at 10 μM, while viridecalin C showcases the most potent reactivation activity, indicating the potential of application in cancer therapy. |
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| ISSN: | 1660-3397 |