Dysregulation of metabolites and high-altitude illnesses development under plateau conditions
BackgroundUnder plateau conditions, changes in metabolite levels can affect cellular signal transduction, protein activity, and gene expression, thereby inducing a series of physiopathological changes. Altered metabolite signaling in plateau environments may be associated with the onset and progress...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2025.1600374/full |
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| Summary: | BackgroundUnder plateau conditions, changes in metabolite levels can affect cellular signal transduction, protein activity, and gene expression, thereby inducing a series of physiopathological changes. Altered metabolite signaling in plateau environments may be associated with the onset and progression of high-altitude illnesses. This review summarizes the effects of a plateau environment on diseases, the mechanism of occurrence of such high-altitude illnesses, and the regulation of diseases by metabolites and proposes the role of metabolites in regulating high-altitude illnesses in plateau environments.Main bodyThrough a systematic review and analysis of the existing literature, we propose and focus on an original theoretical framework for the metabolic regulation of high-altitude illnesses. We hypothesize that the development of high-altitude illnesses is not merely a reflection of passive changes in metabolites but rather stems from an imbalance in a recognizable and intervenable metabolic regulatory network.ConclusionMetabolites have very important roles and implications in high-altitude illnesses, and a better comprehension of the regulatory role of metabolites in the pathogenesis of high-altitude illnesses can provide theoretical support for the prevention and treatment of high-altitude illnesses. |
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| ISSN: | 1664-042X |