Allele distribution of D5S125, MAP1B5' and D5S679 microsatellite markers in Turkish spinal muscular atrophy families
Spinal muscular atrophy (SMA) is an autosomal recessive disease and one of the most common genetic causes of death in childhood. The gene for SMA has been mapped to chromosome 5q11.2-13.3. Chromosomal distribution of the alleles of D5S125, MAP1B5' and D5S679 polymorphic microsatellite ma...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
1997-10-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/3423 |
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| _version_ | 1850033396071268352 |
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| author | H Erdem S Pehlivan H Topaloğlu I Togan M Ozgüç |
| author_facet | H Erdem S Pehlivan H Topaloğlu I Togan M Ozgüç |
| author_sort | H Erdem |
| collection | DOAJ |
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Spinal muscular atrophy (SMA) is an autosomal recessive disease and one of the most common genetic causes of death in childhood. The gene for SMA has been mapped to chromosome 5q11.2-13.3. Chromosomal distribution of the alleles of D5S125, MAP1B5' and D5S679 polymorphic microsatellite markers in 14 unrelated Turkish SMA families have been determined. It is observed that the A9 allele of D5S679 has a significant (chi 2: 3.41 p: 0.065) non-random association with mutant chromosomes.
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| format | Article |
| id | doaj-art-62d92bf1ec6c49c3b6e9714582aa91bd |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 1997-10-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-62d92bf1ec6c49c3b6e9714582aa91bd2025-08-20T02:58:14ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64211997-10-01394Allele distribution of D5S125, MAP1B5' and D5S679 microsatellite markers in Turkish spinal muscular atrophy familiesH Erdem0S PehlivanH TopaloğluI ToganM OzgüçDepartment of Medical Biology, Hacettepe University Faculty of Medicine, Ankara, Turkey. Spinal muscular atrophy (SMA) is an autosomal recessive disease and one of the most common genetic causes of death in childhood. The gene for SMA has been mapped to chromosome 5q11.2-13.3. Chromosomal distribution of the alleles of D5S125, MAP1B5' and D5S679 polymorphic microsatellite markers in 14 unrelated Turkish SMA families have been determined. It is observed that the A9 allele of D5S679 has a significant (chi 2: 3.41 p: 0.065) non-random association with mutant chromosomes. https://turkjpediatr.org/article/view/3423 |
| spellingShingle | H Erdem S Pehlivan H Topaloğlu I Togan M Ozgüç Allele distribution of D5S125, MAP1B5' and D5S679 microsatellite markers in Turkish spinal muscular atrophy families The Turkish Journal of Pediatrics |
| title | Allele distribution of D5S125, MAP1B5' and D5S679 microsatellite markers in Turkish spinal muscular atrophy families |
| title_full | Allele distribution of D5S125, MAP1B5' and D5S679 microsatellite markers in Turkish spinal muscular atrophy families |
| title_fullStr | Allele distribution of D5S125, MAP1B5' and D5S679 microsatellite markers in Turkish spinal muscular atrophy families |
| title_full_unstemmed | Allele distribution of D5S125, MAP1B5' and D5S679 microsatellite markers in Turkish spinal muscular atrophy families |
| title_short | Allele distribution of D5S125, MAP1B5' and D5S679 microsatellite markers in Turkish spinal muscular atrophy families |
| title_sort | allele distribution of d5s125 map1b5 and d5s679 microsatellite markers in turkish spinal muscular atrophy families |
| url | https://turkjpediatr.org/article/view/3423 |
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