Physicochemical quality assessment of four asparaginases.

L-Asparaginases (ASNases) are used for the treatment of acute lymphoblastic leukaemia. There are reports of quality problems for some therapeutic asparaginase products, especially those manufactured in middle-income countries. These products may exhibit decreased potency and/or decreased specific ac...

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Bibliographic Details
Main Authors: Vanessa Radtke, Thorsten König, Christoph Radcke, Ulf Bergmann, Rene Eichler, Katja J Pohl, Arndt Schnuchel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0326106
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