WNT-induced association of Frizzled and LRP6 is not sufficient for the initiation of WNT/β-catenin signaling

WNT-induced association of Frizzled and LRP6 is not sufficient for the initiation of WNT/β-catenin signaling

Abstract The Wingless/Int-1 (WNT) signaling network is essential to orchestrate central physiological processes such as embryonic development and tissue homeostasis. In the currently held tenet, WNT/β-catenin signaling is initiated by WNT-induced recruitment of Frizzleds (FZDs) and LRP5/6 followed b...

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Main Authors: Jan Hendrik Voss, Zsombor Koszegi, Yining Yan, Emily Shorter, Lukas Grätz, Johanna T. Lanner, Davide Calebiro, Gunnar Schulte
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60096-7
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