Increased PD-1 expression in livers associated with PD-1-antibody-induced hepatotoxicity

Increased PD-1 expression in livers associated with PD-1-antibody-induced hepatotoxicity

Abstract Vanishing bile duct syndrome (VBDS) is a serious drug induced liver injury characterized by chronic cholestasis and loss of intrahepatic bile ducts. VBDS has been reported also following checkpoint inhibitor treatment. We compared CD3 + , CD4 + , CD8 + , CD20 + , CD57 + , PD-1 + and PD-L1 +...

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Main Authors: Miro Saarela, Essi Parviainen, Ana Lleo, Luca di Tommaso, Hanna Raunio, Krista Kankaanranta, Katri Vuopala, Aino Rönkä, Sini Nurmenniemi, Raija Kallio, Arja Jukkola, Katri S. Selander
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Immunology
Subjects:
Checkpoint inhibitors
Adverse event
Lymphocyte infiltration
Online Access:https://doi.org/10.1186/s12865-025-00682-y
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