Reversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product
The increasing popularity of herbal medicine and the well-established health benefits of phytochemicals have spurred the multiplicity of nutraceutical and phytopharmaceutical products. In this study, Trévo™, a nutraceutical and phytopharmaceutical product, was evaluated for beneficial effects in ace...
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| Format: | Article |
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Tsinghua University Press
2017-03-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453016300891 |
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| author | Afolabi C. Akinmoladun Kehinde O. Oguntunde Lawrence O. Owolabi Omotayo B. Ilesanmi Joan O. Ogundele M.Tolulope Olaleye Afolabi A. Akindahunsi |
| author_facet | Afolabi C. Akinmoladun Kehinde O. Oguntunde Lawrence O. Owolabi Omotayo B. Ilesanmi Joan O. Ogundele M.Tolulope Olaleye Afolabi A. Akindahunsi |
| author_sort | Afolabi C. Akinmoladun |
| collection | DOAJ |
| description | The increasing popularity of herbal medicine and the well-established health benefits of phytochemicals have spurred the multiplicity of nutraceutical and phytopharmaceutical products. In this study, Trévo™, a nutraceutical and phytopharmaceutical product, was evaluated for beneficial effects in acetaminophen-induced hepatic toxicity in Wistar rats. Animals received Trévo™ (1.5 mL/kg, 3.0 mL/kg or 4.5 mL/kg) orally for 14 days. Hepatotoxicity was induced by the oral administration of acetaminophen (2 g/kg), 24 h prior to sacrifice. Biochemical liver function tests, oxidative stress indicators and histoarchitectural changes were evaluated. Acetaminophen administration occasioned significant increase (P < 0.05) in serum bilirubin level and activities of the aminotransferases, alkaline phosphatase, γ-glutamyltransferase and lactate dehydrogenase accompanied by a significant decrease (P < 0.05) in albumin level as well as histopathological alterations in liver sections. Promotion of hepatic oxidative stress by acetaminophen was revealed by significant (P < 0.05) increase in lipid peroxidation, depletion of reduced glutathione, and decrease in superoxide dismutase and catalase activities. Administration of Trévo™ remarkably ameliorated acetaminophen-induced histopathological alterations and changes in serum and tissue biochemical markers. The protective effect of Trévo™ (4.5 mL/kg) was at par with that of Silymarin (25 mg/kg). The present study indicates that Trévo™ has notable salubrious effects. |
| format | Article |
| id | doaj-art-62c1cb9126fb4aa9ac00cce346564143 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-62c1cb9126fb4aa9ac00cce3465641432025-02-03T06:49:12ZengTsinghua University PressFood Science and Human Wellness2213-45302017-03-0161202710.1016/j.fshw.2016.11.001Reversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical productAfolabi C. Akinmoladun0Kehinde O. Oguntunde1Lawrence O. Owolabi2Omotayo B. Ilesanmi3Joan O. Ogundele4M.Tolulope Olaleye5Afolabi A. Akindahunsi6Phytomedicine, Biochemical and Molecular Pharmacology and Toxicology Laboratories, Department of Biochemistry, School of Sciences, The Federal University of Technology, PMB 704, Akure, NigeriaPhytomedicine, Biochemical and Molecular Pharmacology and Toxicology Laboratories, Department of Biochemistry, School of Sciences, The Federal University of Technology, PMB 704, Akure, NigeriaPhytomedicine, Biochemical and Molecular Pharmacology and Toxicology Laboratories, Department of Biochemistry, School of Sciences, The Federal University of Technology, PMB 704, Akure, NigeriaPhytomedicine, Biochemical and Molecular Pharmacology and Toxicology Laboratories, Department of Biochemistry, School of Sciences, The Federal University of Technology, PMB 704, Akure, NigeriaDepartment of Industrial Chemistry, Faculty of Science, Federal University Oye-Ekiti, PMB 373, Oye-Ekiti, NigeriaPhytomedicine, Biochemical and Molecular Pharmacology and Toxicology Laboratories, Department of Biochemistry, School of Sciences, The Federal University of Technology, PMB 704, Akure, NigeriaPhytomedicine, Biochemical and Molecular Pharmacology and Toxicology Laboratories, Department of Biochemistry, School of Sciences, The Federal University of Technology, PMB 704, Akure, NigeriaThe increasing popularity of herbal medicine and the well-established health benefits of phytochemicals have spurred the multiplicity of nutraceutical and phytopharmaceutical products. In this study, Trévo™, a nutraceutical and phytopharmaceutical product, was evaluated for beneficial effects in acetaminophen-induced hepatic toxicity in Wistar rats. Animals received Trévo™ (1.5 mL/kg, 3.0 mL/kg or 4.5 mL/kg) orally for 14 days. Hepatotoxicity was induced by the oral administration of acetaminophen (2 g/kg), 24 h prior to sacrifice. Biochemical liver function tests, oxidative stress indicators and histoarchitectural changes were evaluated. Acetaminophen administration occasioned significant increase (P < 0.05) in serum bilirubin level and activities of the aminotransferases, alkaline phosphatase, γ-glutamyltransferase and lactate dehydrogenase accompanied by a significant decrease (P < 0.05) in albumin level as well as histopathological alterations in liver sections. Promotion of hepatic oxidative stress by acetaminophen was revealed by significant (P < 0.05) increase in lipid peroxidation, depletion of reduced glutathione, and decrease in superoxide dismutase and catalase activities. Administration of Trévo™ remarkably ameliorated acetaminophen-induced histopathological alterations and changes in serum and tissue biochemical markers. The protective effect of Trévo™ (4.5 mL/kg) was at par with that of Silymarin (25 mg/kg). The present study indicates that Trévo™ has notable salubrious effects.http://www.sciencedirect.com/science/article/pii/S2213453016300891AcetaminophenAntioxidant activityHepatoprotectionNutraceuticalHerbal supplement |
| spellingShingle | Afolabi C. Akinmoladun Kehinde O. Oguntunde Lawrence O. Owolabi Omotayo B. Ilesanmi Joan O. Ogundele M.Tolulope Olaleye Afolabi A. Akindahunsi Reversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product Food Science and Human Wellness Acetaminophen Antioxidant activity Hepatoprotection Nutraceutical Herbal supplement |
| title | Reversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product |
| title_full | Reversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product |
| title_fullStr | Reversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product |
| title_full_unstemmed | Reversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product |
| title_short | Reversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product |
| title_sort | reversal of acetaminophen generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product |
| topic | Acetaminophen Antioxidant activity Hepatoprotection Nutraceutical Herbal supplement |
| url | http://www.sciencedirect.com/science/article/pii/S2213453016300891 |
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