Systemic longitudinal immune profiling identifies proliferating Treg cells as predictors of immunotherapy benefit: biomarker analysis from the phase 3 CONTINUUM and DIPPER trials

Systemic longitudinal immune profiling identifies proliferating Treg cells as predictors of immunotherapy benefit: biomarker analysis from the phase 3 CONTINUUM and DIPPER trials

Abstract The identification of predictors for immunotherapy is often hampered by the absence of control groups in many studies, making it difficult to distinguish between prognostic and predictive biomarkers. This study presents biomarker analyses from the phase 3 CONTINUUM trial (NCT03700476), the...

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Main Authors: Sai-Wei Huang, Wei Jiang, Sha Xu, Yuan Zhang, Juan Du, Ya-Qin Wang, Kun-Yu Yang, Ning Zhang, Fang Liu, Guo-Rong Zou, Feng Jin, Hai-Jun Wu, Yang-Ying Zhou, Xiao-Dong Zhu, Nian-Yong Chen, Cheng Xu, Han Qiao, Na Liu, Ying Sun, Jun Ma, Ye-Lin Liang, Xu Liu
Format: Article
Language:English
Published: Nature Publishing Group 2024-10-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-024-01988-w
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