Exosomes and their cargo proteins in diagnosis, process and treatment of gastric cancer
Gastric cancer is one of the common malignant tumors of digestive tract. Early diagnosis, process monitoring, and appropriate treatment strategies are crucial to reducing mortality and improving patient outcomes. However, the lack of specific early symptoms and reliable diagnostic markers often lead...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1560583/full |
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| author | Wenjing Lu Wenjing Lu Minghan Li Minghan Li DanZeng LaMu DanZeng LaMu Hui Qian Hui Qian Zhaofeng Liang Zhaofeng Liang Xuezhong Xu |
| author_facet | Wenjing Lu Wenjing Lu Minghan Li Minghan Li DanZeng LaMu DanZeng LaMu Hui Qian Hui Qian Zhaofeng Liang Zhaofeng Liang Xuezhong Xu |
| author_sort | Wenjing Lu |
| collection | DOAJ |
| description | Gastric cancer is one of the common malignant tumors of digestive tract. Early diagnosis, process monitoring, and appropriate treatment strategies are crucial to reducing mortality and improving patient outcomes. However, the lack of specific early symptoms and reliable diagnostic markers often leads to delayed diagnosis and suboptimal treatment strategies. Exosomes, as small vesicular structures derived from endosomes, play crucial roles in cell-to-cell communication and have emerged as promising biomarkers and therapeutic targets in various cancers, including gastric cancer. This comprehensive review delves into the significance of exosomes and their cargo proteins, particularly focusing on their applications in the diagnosis, progress and treatment of gastric cancer. Based on this review, we believe that the real-time release characteristics of extracellular vesicle proteins make them an ideal tool for dynamically monitoring gastric cancer progression and treatment response. The potential of extracellular vesicles in “liquid biopsy” can be explored to replace traditional invasive examinations and achieve non-invasive and continuous disease monitoring. In the future, nanotechnology can be combined with artificial intelligence to develop an efficient extracellular vesicle protein capture and analysis platform, in order to enhance diagnostic sensitivity and specificity. |
| format | Article |
| id | doaj-art-62b2ea4b01cf427faa1506d6b5df6e21 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-62b2ea4b01cf427faa1506d6b5df6e212025-08-20T03:49:50ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-07-011310.3389/fcell.2025.15605831560583Exosomes and their cargo proteins in diagnosis, process and treatment of gastric cancerWenjing Lu0Wenjing Lu1Minghan Li2Minghan Li3DanZeng LaMu4DanZeng LaMu5Hui Qian6Hui Qian7Zhaofeng Liang8Zhaofeng Liang9Xuezhong Xu10Wujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated With Jiangsu University, Changzhou, Jiangsu, ChinaJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, ChinaWujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated With Jiangsu University, Changzhou, Jiangsu, ChinaJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, ChinaWujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated With Jiangsu University, Changzhou, Jiangsu, ChinaJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, ChinaWujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated With Jiangsu University, Changzhou, Jiangsu, ChinaJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, ChinaWujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated With Jiangsu University, Changzhou, Jiangsu, ChinaJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, ChinaWujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated With Jiangsu University, Changzhou, Jiangsu, ChinaGastric cancer is one of the common malignant tumors of digestive tract. Early diagnosis, process monitoring, and appropriate treatment strategies are crucial to reducing mortality and improving patient outcomes. However, the lack of specific early symptoms and reliable diagnostic markers often leads to delayed diagnosis and suboptimal treatment strategies. Exosomes, as small vesicular structures derived from endosomes, play crucial roles in cell-to-cell communication and have emerged as promising biomarkers and therapeutic targets in various cancers, including gastric cancer. This comprehensive review delves into the significance of exosomes and their cargo proteins, particularly focusing on their applications in the diagnosis, progress and treatment of gastric cancer. Based on this review, we believe that the real-time release characteristics of extracellular vesicle proteins make them an ideal tool for dynamically monitoring gastric cancer progression and treatment response. The potential of extracellular vesicles in “liquid biopsy” can be explored to replace traditional invasive examinations and achieve non-invasive and continuous disease monitoring. In the future, nanotechnology can be combined with artificial intelligence to develop an efficient extracellular vesicle protein capture and analysis platform, in order to enhance diagnostic sensitivity and specificity.https://www.frontiersin.org/articles/10.3389/fcell.2025.1560583/fullexosomesproteinsdiagnosisoccurrencedevelopmenttreatment |
| spellingShingle | Wenjing Lu Wenjing Lu Minghan Li Minghan Li DanZeng LaMu DanZeng LaMu Hui Qian Hui Qian Zhaofeng Liang Zhaofeng Liang Xuezhong Xu Exosomes and their cargo proteins in diagnosis, process and treatment of gastric cancer Frontiers in Cell and Developmental Biology exosomes proteins diagnosis occurrence development treatment |
| title | Exosomes and their cargo proteins in diagnosis, process and treatment of gastric cancer |
| title_full | Exosomes and their cargo proteins in diagnosis, process and treatment of gastric cancer |
| title_fullStr | Exosomes and their cargo proteins in diagnosis, process and treatment of gastric cancer |
| title_full_unstemmed | Exosomes and their cargo proteins in diagnosis, process and treatment of gastric cancer |
| title_short | Exosomes and their cargo proteins in diagnosis, process and treatment of gastric cancer |
| title_sort | exosomes and their cargo proteins in diagnosis process and treatment of gastric cancer |
| topic | exosomes proteins diagnosis occurrence development treatment |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1560583/full |
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